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Africa Resilience Initiative

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The mission of this working group is to articulate and shape issues of resilience and sustainability on the continent of Africa as they may be implemented as reforms of current policies, as well as contemplate and make recommendations for more extensive critiques and proposals for national, provincial, and local systems transformation, as may be necessary or desirable beyond the scope of traditional reforms being undertaken by the current African national governments and local government proposals in Africa.

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This working group is focused on developing an Africa Resilience Initiative to ensure resilience and sustainability for all Africans.
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Members

Aboubacar Conte admin Anthony bnorton Carrielaj Chisina Kapungu
ChrisAllen craig.sevcik Dr Ojia Adamolekun efrost Elhadj Drame Grace Kim
Hadiatou Balde jranck Kathy Gilbeaux mdmcdonald MDMcDonald_me_com mike kraft
njchapman Norea SmShako TacarraB Tjivekumba Kandjii

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Vodafone Launches Mobile Cash Transfer System in Ghana Where 15M People Do Not Have a Bank Account

             

Moving money: The service, called M-Pesa, will be branded Vodafone Cash in the West African state

thisismoney.co.uk - by City & Finance Reporter for the Daily Mail - December 7, 2015

Vodafone has launched its mobile cash transfer system in Ghana where 15m people do not have a bank account.

The service, called M-Pesa, will be branded Vodafone Cash in the West African state. It allows mobile phone users to load money on to their phones, just as pay-as-you-go customers can top up their credit. 

They can send the funds anywhere in the country with a text message. Recipients can pick up the cash at shops that offer the service.

(READ COMPLETE ARTICLE)

 

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Mathematical Modeling of the West Africa Ebola Epidemic

eLife 2015;10.7554/eLife.09186 - December 8, 2015
DOI: http://dx.doi.org/10.7554/eLife.09186

Abstract

As of November 2015, the Ebola virus disease (EVD) epidemic that began in West Africa in late 2013 is waning. The human toll includes more than 28,000 Ebola virus disease (EVD) cases and 11,000 deaths in Guinea, Liberia, and Sierra Leone, the most heavily-affected countries. We reviewed 66 mathematical modeling studies of the EVD epidemic published in the peer-reviewed literature to assess the key uncertainties models addressed, data used for modeling, public sharing of data and results, and model performance. Based on the review, we suggest steps to improve the use of modeling in future public health emergencies.

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Identification of NPC1 as the Target of U18666A, an Inhibitor of Lysosomal Cholesterol Export and Ebola Infection

eLife 2015;10.7554/eLife.12177 - DECEMBER 8, 2015
DOI: http://dx.doi.org/10.7554/eLife.12177

Abstract

Niemann-Pick C1 (NPC1) is a lysosomal membrane protein that exports cholesterol derived from receptor-mediated uptake of LDL, and it also mediates cellular entry of Ebola virus. Cholesterol export is inhibited by nanomolar concentrations of U18666A, a cationic sterol. To identify the target of U18666A, we synthesized U-X, a U18666A derivative with a benzophenone that permits ultraviolet-induced crosslinking. When added to CHO cells, U-X crosslinked to NPC1. Crosslinking was blocked by U18666A derivatives that block cholesterol export, but not derivatives lacking blocking activity. Crosslinking was prevented by point mutation in the sterol-sensing domain (SSD) of NPC1, but not by point mutation in the N-terminal domain (NTD). These data suggest that the SSD contains a U18666A-inhibitable site required for cholesterol export distinct from the cholesterol-binding site in the NTD. Inasmuch as inhibition of Ebola requires 100-fold higher concentrations of U18666A, the high affinity U16888A-binding site is likely not required for virus entry. 

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At Climate Talks, African Nations Pledge to Restore Forests

         

FILE - In this Sunday, March 21, 2010 file photo, shafts of sunlight filtering through the forest canopy strike smoke from fires burning outside family huts at an Mbuti pygmy hunting camp in the Okapi Wildlife Reserve outside the town of Epulu, Congo. Tree by tree, more than a dozen African governments pledged to restore the continent’s natural forests at the U.N. climate change talks in Paris on Sunday, Dec. 6, 2015. (Rebecca Blackwell,File/Associated Press)

CLICK HERE - World Resources Institute - African Countries Launch AFR100 to Restore 100 Million Hectares of Land

CLICK HERE - African Forest Landscape Restoration Initiative (AFR100)

CLICK HERE - Global Landscapes Forum

washingtonpost.com - by Lynsey Chutel - December 6, 2015

JOHANNESBURG — Tree by tree, more than a dozen African governments pledged to restore the continent’s natural forests at the United Nations climate talks on Sunday.

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How Climate Change is Behind the Surge of Migrants to Europe

             

Migrants and refugees arrive on Sykamia beach, west of the port of Mytilene, on the Greek island of Lesbos after crossing the Aegean sea from Turkey, on Sept. 22, 2015.  Iakovos Hatzistavrou—AFP/Getty Images

Even as Europe wrestles over how to absorb the migrant tide, experts warn that the flood is likely to get worse as climate change becomes a driving factor.

time.com - by Aryn Baker - September 7, 2015

. . . “You think migration is a challenge to Europe today because of extremism, wait until you see what happens when there’s an absence of water, an absence of food, or one tribe fighting against another for mere survival,” . . .

. . . Security analysts say they are already seeing the impact, particularly in migration patterns from northern Africa and the Sahel region, which is the band of farmland just below the Sahara desert. “All the indicators seem to fairly solidly convey that climate change — desertification and lack of water, or floods, are massively contributing to human mobility . . .

(READ COMPLETE ARTICLE)

 
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Liberia: 'Blood Transfusion' - Responsible For New Ebola Outbreak

allafrica.com - November 27, 2015

Investigation conducted by this paper has established that unsafe blood transfusion is probably responsible for the new Ebola outbreak in Liberia.

A 15-year-old-boy was last weekend tested positive for Ebola and later pronounced dead on Tuesday. Dr. Francis Kateh, Chief Medical Officer of Liberia, said the boy's parents have also been tested positive for the virus and were undergoing observation.

The Ministry of Health and its partners are yet to disclose the source of the new outbreak, but a weeklong investigation conducted by this paper has established that blood recently transfused into the boy's mother at the Benson Hospital in Paynesville is the probable cause of the new Ebola infection.

(READ COMPLETE ARTICLE)

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Study Blocks Ebola Virus Budding By Regulating Calcium Signalling

submitted by George Hurlburt

                                                  

scicasts.com - November 2, 2015

CLICK HERE - STUDY - Calcium Regulation of Hemorrhagic Fever Virus Budding: Mechanistic Implications for Host-Oriented Therapeutic Intervention - Ziying Han, Jonathan J. Madara et al. PLOS Pathogens (2015)

Philadelphia, PA (Scicasts) — The Ebola virus acts fast. The course of infection, from exposure to recovery, or death, can take as little as two weeks. That may not leave enough time for the immune system to mount an effective response.

The goal of some anti-viral therapies, therefore, is to buy more and give the immune system a leg up on the virus. A new study led by Bruce Freedman and Ronald Harty in the Department of Pathobiology of the University of Pennsylvania School of Veterinary Medicine demonstrates a way to do that, by reducing the ability of the virus to exit a host cell and spread. Their work showed that blocking a calcium-signalling pathway could inhibit not only the Ebola virus, but also Marburg, Lassa and Junin viruses, all sources of deadly infections.

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Another American Ebola Survivor Had Eye Problems

Ebola survivor Dr. Richard Sacra experienced eye problems, including vision loss, pain and redness, shortly after he recovered from the disease.

Credit: Chancellor JR, Padmanabhan SP, Greenough TC, Sacra R, Ellison RT III, Madoff LC, et al. Uveitis and systemic inflammatory markers in convalescent phase of Ebola virusdisease. Emerg Infect Dis. 2016 Feb

CLICK HERE - STUDY - CDC - Uveitis and Systemic Inflammatory Markers in Convalescent Phase of Ebola Virus Disease

livescience.com - by Rachael Rettner - November 25, 2015

Ebola survivor Dr. Ian Crozier wasn't the only American to experience eye problems following the disease — a new report describes eye problems in another American doctor who lived through the disease.

Dr. Richard Sacra, who works for the Christian mission organization SIM USA, contracted Ebola last year while caring for pregnant women in Liberia during the rise of the Ebola outbreak there. He was evacuated to the United States for treatment in early September 2014, and was declared Ebola-free after spending about a month in the hospital.

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Panels Advise Bolstering W.H.O. for Crises Like Ebola

nytimes.com - by Sheri Fink - November 22, 2015

In recent months, numerous groups of health experts have gathered to debate how to prevent another crisis like the Ebola epidemic in West Africa, which jumped borders, spread fear across the globe, and directly killed more than 11,000 people. Many more died as hospitals and clinics closed for months.

Now two of those groups — one independent and the other convened by the World Health Organization — have released specific recommendations and called for urgent action. Both concluded that the W.H.O.’s outbreak and emergency response capacities should be strengthened and consolidated, protected from political meddling and independently overseen. The health organization is a United Nations agency.

(READ COMPLETE ARTICLE)

CLICK HERE - WHO - Advisory Group on Reform of WHO’s Work in Outbreaks and Emergencies with Health and Humanitarian Consequences

CLICK HERE - WHO - First report of the Advisory Group on Reform of WHO’s work in outbreaks and emergencies (20 page .PDF report)

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