For years, scientists and doctors have treated vaccine skepticism as a knowledge problem. If patients were hesitant to get vaccinated, the thinking went, they simply needed more information.

But as public health officials now work to convince Americans to get Covid-19 vaccines as quickly as possible, new social science research suggests that a set of deeply held beliefs is at the heart of many people’s resistance, complicating efforts to bring the coronavirus pandemic under control.

“The instinct from the medical community was, ‘If only we could educate them,’” said Dr. Saad Omer, director of the Yale Institute for Global Health, who studies vaccine skepticism. “It was patronizing and, as it turns out, not true.”