Vaccines

Current COVID boosters offer good protection against severe outcomes but less so against JN.1 The current COVID-19 boosters targeting the Omicron XBB.1.5 subvariant are still offering solid protection against infection, hospitalizations, and death, but are somewhat limited in efficacy against illnesses caused by the JN.1 subvariant, now the dominant strain in the United States, according to a research letter yesterday in the New England Journal of Medicine. CIDRAP

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Extreme weather. A lack of lifesaving vaccines. Africa's cholera crisis is worse than ever (medicalxpress.com)

Extreme weather events have hit parts of Africa relentlessly in the last three years, with tropical storms, floods and drought causing crises of hunger and displacement. They leave another deadly threat behind them: some of the continent's worst outbreaks of cholera.

In southern and East Africa, more than 6,000 people have died and nearly 350,000 cases have been reported since a series of cholera outbreaks began in late 2021.....

All have experienced floods or drought—in some cases, both—and health authorities, scientists and aid agencies say the unprecedented surge of the water-borne bacterial infection in Africa is the newest example of how extreme weather is playing a role in driving disease outbreaks.

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HHS advances plan to produce 4.8 million H5N1 vaccine doses Officials have identified a fill-and-finish opening on a production line at a vaccine company partner and said the activity won't disrupt the supply of seasonal flu vaccine. CIDRAP

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Dawn O'Connell, JD, said health officials have identified a manufacturing line at one of its manufacturing partners for fill-and-finish steps, without disrupting production of seasonal flu vaccine. Currently, the vaccine is in bulk form and will be produced in multidose vials.

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Study shows vaccination lowers risk of long COVID COVID-19 patients vaccinated against the novel coronavirus were less likely to have symptoms of post-COVID condition (PCC), or long COVID, according to a new study in Nature Communications. CIDRAP

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In other long-COVID research news, a study in the International Journal of Infectious Diseases describes new estimates of long-COVID incidence and clinical study trends in a number of regions.