Africa

PLOS PATHOGENS  by Marc-Antoine de La Vega,  Derek Stein, and GaryKopinger, University of Manitoba, Canada , Nov. 12, 2015    

Winnipeg, Manitoba, Canada The past year has marked the most devastating Ebola outbreak the world has ever witnessed, with over 28,000 cases and over 11,000 deaths. Ebola virus (EBOV) has now been around for almost 50 years. In this review, we discuss past and present outbreaks of EBOV and how those variants evolved over time. We explore and discuss selective pressures that drive the evolution of different Ebola variants, and how they may modify the efficacy of therapeutic treatments and vaccines currently being developed. Finally, given the unprecedented size and spread of the outbreak, as well as the extended period of replication in human hosts, specific attention is given to the 2014–2015 West African outbreak variant (Makona).

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http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1005221

reuters.com - Reporting by Saliou Samb; Writing by Makini Brice; Editing by Digby Lidstone - November 14, 2015

The final 68 people who had been in contact with an Ebola patient were released from quarantine on Saturday, said a senior health official, raising hopes of an end to the disease in the last West African country with confirmed cases.

The world's worst Ebola epidemic, which hopped borders to kill more than 11,300 people and devastate already fragile West African economies, has already been declared over in Liberia and Sierra Leone. But Guinea, where the outbreak began, has had a more difficult time eradicating the disease.

Dr. Abdourahmane Bathily, head of the Ebola center in Forecariah in western Guinea, said the 68 contacts had emerged from quarantine at midnight on Saturday morning.

"There are no longer any people who had contact with a person infected by the Ebola virus," said Bathily.

He added that the last confirmed Ebola case was a baby in isolation, who should be released from a treatment center next week, allowing for the West African nation to begin its own countdown clock.

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submitted by George Hurlburt

CLICK HERE - STUDY - Transmission network of the 2014–2015 Ebola epidemic in Sierra Leone

livescience.com - by Agata Blaszczak-Boxe - November 10, 2015

A new map reveals the path that the Ebola virus took during the outbreak in Sierra Leone, giving a detailed picture of how and where the disease spread, a new study said.

The researchers made the map using a new statistical model, and they say it could be used in the future to improve the way help is delivered to outbreak regions.

"For a future outbreak, this is something that can be readily applied to help identify the regions that need intervention most critically," said study author Jeffrey Shaman, an associate professor of environmental health sciences at Columbia University's Mailman School of Public Health. The model could help authorities figure out where to best deploy people to respond to the outbreak, he said.

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US NEWS AND WORLD REPORT HEALTHDAY NEWS by Robert Preidt,  Nov. 6, 2015

Ebola patients are more likely to survive if they are hospitalized soon after being infected, a new study finds.

Researchers analyzed data from nearly 1,000 cases of Ebola virus that occurred in the Democratic Republic of Congo over 38 years. They found that each day of delay in hospital admission was associated with an 11 percent higher risk of death during epidemics.

Delays in hospitalization were caused by factors such as geography, infrastructure and cultural influences, the researchers said.

The Democratic Republic of Congo has had more Ebola outbreaks than any other country since the deadly virus was discovered in 1976, they noted.

The researchers also found that rapidly progressing Ebola outbreaks are swiftly brought under control, while national and international responses to slower-progressing outbreaks tend to be less intense. As a result, those outbreaks last longer, the study authors said.

The study was published Nov. 3 in the journal eLife.

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http://health.usnews.com/health-news/articles/2015/11/06/each-1-day-delay-in-hospitalization-ups-risk-of-ebola-death