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Ebola vaccine trials could start in Africa in January

UPDATE: Drugmakers to join forces to make millions of Ebola vaccine doses

REUTERS                                                                     Oct 22, 2014

By Ben Hirschler

LONDON -- Leading drugmakers plan to work together to speed up the development of an Ebola vaccine and hope to produce millions of doses for use next year.

U.S. firm Johnson & Johnson said on Wednesday that it aims to produce at least 1 million doses of its two-step vaccine next year and has already discussed collaboration with Britain's GlaxoSmithKline, which is working on a rival vaccine.

The economics of an Ebola vaccine are still unclear but drug companies with an eye on their reputations are under pressure to respond to the major international health crisis now ravaging one of the poorest corners of Africa.

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Ebola crisis: Worst-hit African nations get key supplies

BBC                                                                                   Oct. 20, 2014

Vital supplies and resources to tackle Ebola are beginning to arrive in the three worst-hit West African countries, Ghana's President John Mahama has said.

Mr Mahama, who heads the regional bloc Ecowas, also told the BBC that treatment centres were being set up in Guinea, Liberia and Sierra Leone. But he called for proper co-ordination between agencies to avoid duplication.


Red Cross workers are among those fighting the outbreak in Sierra Leone

Mr Mahama told the BBC that the World Food Programme was airlifting humanitarian aid to Liberia, Sierra Leone and Guinea.

"Vehicles, motorcycles and other means of transport are going in there. There's more protective clothing being provided," he said.

"But there's no need for us to duplicate each other and have more treatment centres when we do not have volunteers and health workers to treat the people in the treatment centres.

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Special Report - A Primer on Ebola for Clinicians

journals.cambridge.org -  Eric Toner, Amesh Adalja and Thomas Inglesby. A Primer on Ebola for Clinicians.
Disaster Medicine and Public Health Preparedness, available on CJO2014. doi:10.1017/dmp.2014.115.

Abstract

The size of the world’s largest Ebola outbreak now ongoing in West Africa makes clear that further exportation of Ebola virus disease to other parts of the world will remain a real possibility for the indefinite future. Clinicians outside of West Africa, particularly those who work in emergency medicine, critical care, infectious diseases, and infection control, should be familiar with the fundamentals of Ebola virus disease, including its diagnosis, treatment, and control. In this article we provide basic information on the Ebola virus and its epidemiology and microbiology. We also describe previous outbreaks and draw comparisons to the current outbreak with a focus on the public health measures that have controlled past outbreaks. We review the pathophysiology and clinical features of the disease, highlighting diagnosis, treatment, and hospital infection control issues that are relevant to practicing clinicians. We reference official guidance and point out where important uncertainty or controversy exists. (Disaster Med Public Health Preparedness. 2014;0:1-5)

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Ebola Doctors at Breaking Point: 'This Constant Feeling That the Boat's Sinking'

      

A doctor outside the JFK Ebola treatment center speaks to journalists on Oct. 13, 2014 in Monrovia, Liberia.  Photographer: John Moore/Getty Images
 
bloomberg.com - by Makiko Kitamura and Naomi Kresge - October 20, 2014

At 3:30 a.m. in the world’s biggest Ebola treatment center, Daniel Lucey found the outbreak reduced to its essentials: patients lying on mattresses on the floor and vomiting in the dark, visible only by the wavering flashlight beam of a single volunteer doctor.

“I don’t see a light at the end of the tunnel,” said Lucey, a physician and professor from Georgetown University who is halfway through a five-week tour in Liberia with Medecins Sans Frontieres, the medical charity known in English as Doctors Without Borders. “The epidemic is still getting worse,” he said by phone between shifts.

(READ COMPLETE ARTICLE)

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Review of Human-to-Human Transmission of Ebola Virus

CDC                                                              Posted Oct. 20, 2014 from  CDC  Oct. 17 document

This document is a concise summary of published information on the current science about human-to-human transmission of Ebola virus. It is developed for use by healthcare personnel and public health professionals to use. It is a complement to the many guidance documents that CDC has issued already online at

www.cdc.gov/ebola.

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The Bigger Picture: Ebola - Dr. Michael D. McDonald

RT – Thom Hartmann - The Bigger Picture: Ebola – October 17-18, 2014

Dr. Michael D. McDonald, Robert Walker and DeAnn McEwen – A Discussion on Ebola

To stop Ebola from spreading in West Africa, Dr. Michael D. McDonald, Executive Director of Health Initiatives Foundation Inc. and the Global Resilience System talks about the need to have community strategies where we set up Resilience Capacity Zones to reduce the transmission and the translocation of Ebola. He states we need to create behavioral and social immunity around Ebola-affected areas to reduce the transmission and translocation. We need to create Ebola-resistant, and Ebola-free zones in ring-like fashion.

CLICK HERE - The Bigger Picture: Ebola

http://www.youtube.com/watch?v=FZlUp_aVgxc

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Long Quest for Ebola Vaccine Slowed by Science, Ethics, Politics

An experimental Ebola vaccine has been developed by the U.S. National Institutes of Health and pharmaceutical company GlaxoSmithKline. Photograph by Steve Parsons, AP

Image: An experimental Ebola vaccine has been developed by the U.S. National Institutes of Health and pharmaceutical company GlaxoSmithKline. Photograph by Steve Parsons, AP

news.nationalgeographic.com - October 14th, 2014 - Karen Weintraub

Ebola vaccines are so effective in monkeys that macaques can be protected or rescued even if they're injected with a hundred times the lethal dose of the Ebola virus after vaccination. But no one knows for certain whether the vaccines will work in humans; the vaccines haven't yet been rigorously tested in people.

Just developing the vaccines to test in monkeys was a grueling, decades-long process that has killed scores of macaques since the 1990s.

(VIEW COMPLETE ARTICLE)

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NEJM - Ebola Virus Disease in West Africa — The First 9 Months of the Epidemic and Forward Projections

nejm.org - WHO Ebola Response Team

N Engl J Med 2014; 371:1481-1495 - October 16, 2014 - DOI: 10.1056/NEJMoa1411100

Conclusions

These data indicate that without drastic improvements in control measures, the numbers of cases of and deaths from EVD are expected to continue increasing from hundreds to thousands per week in the coming months.

(SEE COMPLETE NEJM ARTICLE HERE)

NEJM - Ebola Virus Disease in West Africa — The First 9 Months of the Epidemic and Forward Projections (15 page .PDF file)

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Ebola: What Should We Do Now?

Four suggestions on what we need to successfully counter Ebola

A healthcare worker mixes chlorine with water at an Ebola treatment center in Hastings, Freetown, Sierra Leone, Oct. 15. Associated Press

Suggestions include:

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Canada to start shipping experimental Ebola vaccine on Monday

CANADIAN PRESS                                     Oct. 18, 2014

OTTAWA—The federal government says Canada will start shipping its experimental Ebola vaccine to the World Health Organization on Monday.

 

 A lab worker at the JC Wilt Infectious Diseases Research centre at Canada's National Microbiology Laboratory in Winnipeg, Manitoba. An experimental Ebola vaccine developed in Canada will be shipped to the World Health Organization in Geneva starting Monday.

The government says in a release the Public Health Agency of Canada is supplying the vaccine to the UN body in Geneva in its role as the international co-ordinating body for the Ebola outbreak in West Africa. It says Canada will ship 800 vials of its experimental vaccine in three separate shipments, as a precautionary measure.

The WHO will consult with its partners, including the health authorities from the affected countries, to determine how best to distribute and use the vaccine. For instance, it must take into account concerns about using an experimental vaccine in people.

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