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Genes Influence How Mice React to Ebola, Study Says In ‘Significant Advance’

NEW YORK TIMES                        Oct. 30, 2014

By Gina Kolata

Some people exposed to the Ebola virus quickly sicken and die. Others become gravely ill but recover, while still others only react mildly or are thought to be resistant to the virus. Now researchers working with mice have found that these laboratory animals, too, can have a range of responses to Ebola, and that in mice, the responses are determined by differences in genes.

Researchers at the University of Washington have been studying the Ebola virus in mice, and have found that the effects of the virus may be determined by genes.Video and photo by University of Washington.

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Most Ebola Patients in the U.S. Survive. Half in Africa Die. Why Are We Letting This Happen?

THE NEW REPUBLIC                                                                      Oct. 29, 2014
ByJonathan Cohen
.... “An Ebola diagnosis need not be a death sentence,” Paul Farmer, an infectious disease specialist at Harvard, wrote in an influential essay for the London Review of Books. “If patients are promptly diagnosed and receive aggressive supportive care—including fluid resuscitation, electrolyte replacement and blood products—the great majority, as many as 90 percent should survive.”

The survival rate in West Africa has been a lot lower than 90 percent...

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Clinical Illness and Outcomes in Patients with Ebola in Sierra Leone

NEW ENGLAND JOURNAL OF MEDICINE

A study and analayisis of patients in Siere Leone suspected of Ebola infections, tested between May 25 and June 18, 2014
Read full report

http://www.nejm.org/doi/full/10.1056/NEJMoa1411680#t=articleTop

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Ebola outbreak: UK aid ship docks in Sierra Leone

The Argus arrives with supplies and medical personnel to assist Serra Leone

 BBC                                                              Oct. 30, 2010

By AndrewHarding

FREETOWN, Sierra Leone--  A British Navy support ship ship has arrived in Sierra Leone to help deal with the deadly Ebola outbreak in the West African country.

Royal Fleet Auxiliary Argus is carrying food, medical equipment, three helicipeters and 32 pick-up trucks, to help keep hard-pressed Ebola treatment centres going.

Doctors, nurses and military personnel are also on board.

The BBC's Africa correspondent Andrew Harding said it would act as an offshore base for the aid effort. and described it as an "important moment".

Read complete story

http://www.bbc.com/news/uk-29836657

 
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Dozens Of Volunteers Have Come Back Safe From Ebola Hot Zone

NBC NEWS                                   Oct. 30, 2014
By Maggie Fox and Stacey Naggiar

Close to 50 volunteers have come back safe and well from the Ebola hot zone in West Africa, aid agencies tell NBC News, even as states debate whether to force such workers into quarantine.

                                                                                    Denmark / U.S. CBP via Reuters file

A look at the numbers from groups such as Doctors Without Borders and the International Medical Corps shows just about 150 people have gone to help fight the epidemic in Liberia, Sierra Leone and Guinea. Of them, 47 have returned symptom-free.

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Home> Health Ebola: Danger in Sierra Leone, Progress in Liberia

UPDATE WITH TEXT OF LATEST WHO REPORT

http://apps.who.int/iris/bitstream/10665/137376/1/roadmapsitrep_29Oct2014_eng.pdf

 

ASSOCIATED PRESS                                                                      Oct. 30, 2014
By CLARENCE ROY-MACAULAY and JONATHAN PAYE-LAYLEH

FREETOWN, Sierra Leone --Liberia is making some progress in containing the Ebola outbreak while Sierra Leone is "in a crisis situation which is going to get worse," the top anti-Ebola officials in the two countries said.

The people of both countries must redouble efforts to stop the disease, which has infected more than 13,000 people and killed nearly 5,000, the officials said. Their assessments underscore that Ebola remains a constant threat until the outbreak is wiped out. It can appear to be on the wane, only to re-emerge in the same place or balloon elsewhere if people don't avoid touching Ebola patients or the bodies of those who succumb to the disease.

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No Ebola, S'il Vous Plait, We're French: The Ivory Coast Mindset

NPR                                                  Oct. 29, 2014
By Gregory Warner

There are all kinds of theories why Ebola hasn't arrived in Ivory Coast, despite the fact that it shares a long and very porous border with two Ebola-afflicted countries, Liberia and Guinea....

 

  Mumadou Traore, a field coordinator for CARE International, says the Ivory Coast's French bureaucracy is a "blessing"    when it comes to Ebola.

Dr. Seydou Coulibaly is the regional health director of Tompki county, which shares the longest border with Liberia and Guinea. He says that in the first weeks of the outbreak, before official prevention directives were issued from the capital, he was telling clinics and hospitals to send him daily Ebola watch reports. He gets a hundred a day. Even before the borders were sealed, he was sending health workers to take people's temperature when they crossed. He's also arranged trainings for schoolteachers and soldiers.

All these efforts will help, he says — maybe not to prevent the virus from coming to the country but at least the first eventual case will be well-managed. That's the main objective.

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Ebola: Better Maps Could Have Helped Fight Virus

How Maps Could Help Fight Ebola

SKY NEWS                                             Oct. 0, 2014

By Tom Cheshire, Technology Correspondent

LONDON -- Better maps could have helped contain the deadly Ebola virus, according to Medecins Sans Frontieres.

Ivan Gaytan, technology advisor to MSF, told Sky News the disease is "preventable" and could have been "easier to contain" if there was more knowledge of the region.

He said: "In any country where Ebola or any other infectious disease arrives, if you already have a good map which actually reflects the way people describe geography, you set up your clinical activities to take that data in the first place in the right way."

MSF, also known as Doctors Without Borders, will launch a project next month called Missing Maps, which lets anyone, anywhere in the world, annotate maps to show dwellings and infrastructure.

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Rate of new Ebola infections in Liberia is slowing, WHO says

OVERVIEW OF DEVELOPMENTS DURING PAST DAY

WASHINGTON POST                            Oct. 30, 2014
By Lena H. Sun, Brady Dennis and Joel Achenbach
New Ebola infections in virus-ravaged Liberia appear to be declining for the first time in months, the World Health Organization said Wednesday.

Until now, officials have been suspicious of this encouraging trend, thinking it might be an artifact of poor data collection, a symptom of chaos in countries that were overwhelmed by the crisis. But Bruce Aylward, a top WHO official, said Wednesday that the decline in new cases “is real,” measured by scores of empty beds in Ebola clinics, fewer cases confirmed by laboratory tests and a drop in burials by specially trained teams.

Still, the WHO and other officials remain wary because the nature of this outbreak has been one of unpredictable surges and declines.

“It’s like saying your pet tiger is under control,” Aylward said. “This is a very, very dangerous disease.”

Meanwhile President Obama continued to criticize the calls for mandatory quarantines for returning volunteers

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Ebola Virus Disease and the Need for New Personal Protective Equipment

JOURNAL OF AMERICAN MEDICICAL ASSOCIATION      Oct. 28, 2014
Michael B. Edmond, MD, MPH, MPA1; Daniel J. Diekema, MD, MS1; Eli N. Perencevich, MD, MS

"...it is clear that reengineering of personal protecion equipment is required, both in US hospitals but more critically for the outbreak zones in Africa. The use of cumbersome PPE in the extreme heat and difficult working conditions of Ebola treatment centers in Africa places great stress on health care workers and limits the time they can spend providing patient care.

" A novel approach to PPE that provides an impermeable fluid barrier that is both more comfortable and easier to don and remove would be a substantial step forward.

"This will require new materials and designs. Indeed, the US Agency for International Development, White House Office of Science and Technology Policy, CDC, and US Department of Defense have recently announced a campaign to develop and test innovations for PPE in response to the Ebola outbreak."

Read complete article
http://jama.jamanetwork.com/article.aspx?articleid=1920943

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