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The contribution of Ebola viral load at admission and other patient characteristics to mortality in a Médecins Sans Frontières (MSF) Ebola Case Management Centre (CMC), Kailahun, Sierra Leone, June –October, 2014

m.jid.oxfordjournals.org - J Infect Dis. (2015) doi: 10.1093/infdis/jiv304 First published online: May 22, 2015

Abstract

This paper describes patient characteristics, including Ebola viral load, associated with mortality in an MSF Ebola case management centre.

Out of 780 admissions between June and October 2014, 525 (67%) were positive for Ebola with a known outcome. The crude mortality rate was 51% (270/525). Ebola viral load (whole blood sample) data was available on 76% (397/525) of patients. Univariate analysis indicated viral load at admission, age, symptom duration prior to admission and distance travelled to the CMC were associated with mortality (p value<0.05). The multivariable model predicted mortality in those with a viral load at admission greater than 10 million copies per millilitre (p value<0.05, Odds Ratio>10), aged 50 years or more (p value=0.08, Odds Ratio=2) and symptom duration prior to admission less than 5 days (p value=0.14). The presence of confusion, diarrhoea and conjunctivitis were significantly higher (p value<0.05) in Ebola patients who died.

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Guinea extends Ebola emergency measures

AFP     JUNE 6, 2015

CONAKRY--Ebola-hit Guinea has extended a health emergency declared in March until the end of June, citing the persistence of the deadly virus in the country, the presidency said on Saturday.


Workers walk at the Donka Ebola treatment center on May 2, 2015 in Conakry (AFP Photo/Cellou Binani)

The decision was taken on Friday by President Alpha Conde, the statement said, after he met his counterpart from Sierra Leone, Ernest Bai Koroma.

In August last year, Conde declared a health emergency for the whole of Guinea. Then on March 28, 2015, he decreed a "reinforced health emergency" for five provinces in the west and southwest of the West African country.

"Given the persistence of the epidemic... in parts of Guinea and Sierra Leone," Conde and Koroma decided "to extend the reinforced emergency measures in their countries until June 30, 2015", the Guinean presidency said.

Read complete story.
http://news.yahoo.com/guinea-extends-ebola-emergency-measures-201127353.html

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West Africa Struggles to Rebuild Its Ravaged Health-Care System

WALL STREET JOURNAL by Betsy McKay  June 4, 2015
HARPER, Liberia --The deadly disease may have receded, but it is still exacting a heavy toll. Run-down, poorly staffed and equipped health facilities allowed Ebola to explode.

 Since it was identified in early 2014, the epidemic has claimed the lives of 507 health-care workers in three West African countries, all of which already were short of medical professionals. The health-care system was so overwhelmed with Ebola victims that many other patients couldn’t receive care for malaria, heart disease or pregnancy complications. That bill is coming due.

“There are more people who are going to die from Ebola, but not have Ebola,” says Paul Farmer, a Harvard professor and co-founder of the Boston-based charity Partners in Health.

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Ebola Response Reveals the Need for New Models for Collaboration Between the Private and Public Sectors

A Report by the World Economic Forum and BCG Analyzes the Private Sector's Response to the Ebola Outbreak and Distills Lessons for Public-Private Partnerships in Future Health Crises

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BOSTON CONSULTING GROUP -MARKETWIRED June 4, 2014

CAPE TOWN, SOUTH AFRICA-- The private sector played an important role in the global response to the Ebola outbreak in West Africa not only by providing financial and in-kind donations but also by acting as a partner to support response activities.

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Global health leaders ask G7 for post-Ebola rapid response unit

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REUTERS by Kate Kelland                                                           June 5, 2015
LONDON -- Global health leaders will ask G7 leaders this weekend to back the creation of a specialist rapid response unit to tackle outbreaks of infectious killer diseases.

The corpse of a patient who passed away is given back to the family for funerals after being decontaminated by the MSF teams. It was washed with chlorine solution and put it in a hermetic bag also disinfected to leave the high risk area.

The move reflects how the World Health Organization in particular was caught unprepared last year by Ebola, which spread through three West African countries, has killed 11,000 people, and will not be stamped out before the end of this year.

Jeremy Farrar, director of the Wellcome Trust global health charity, said the unit should come under the WHO, but be free of bureaucracy and able to act independently "in days" when a potentially fatal epidemic begins...

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Zoloft Could Be a Treatment for Ebola Virus

Researchers have identified two FDA-approved drugs that may be effective against the Ebola virus. This could shorten the time for developing new treatments.

HEALTHLINE NEWS  by  Shawn Radcliffe                                                         June 3, 2015

With a fast-moving epidemic like Ebola, doctors need to make use of every tool at their disposal. This includes giving a second life to already-approved drugs....

One research team is hoping to ease the epidemic by shortening the lengthy drug development process.

Their approach? Sifting through hundreds of existing drugs and other compounds for ones that might work against the Ebola virus....

Additional screening narrowed the list down to two potential drug candidates: Bepridil, a calcium channel blocker used to treat heart disease, and sertraline, an antidepressant more commonly known as Zoloft.

Both drugs are already approved by the FDA, although not for use against the Ebola virus.

Read complete story.

http://www.healthline.com/health-news/zoloft-could-be-a-treatment-for-ebola-virus-060315#1

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Ebola outbreak thrusts MSF into new roles

 Relief agency sees its mission expanding after leading response to West Africa epidemic.

NATURE by  Erika Check Hayden                          June 3, 2015

GENEVA -- Joanne Liu, president of Médecins Sans Frontières (MSF), is not overly concerned with diplomacy. Participating in a panel in Geneva, Switzerland, on 20 May with officials from the United Nations, the World Health Organization (WHO), Liberia and Sierra Leone, she propped her head on her hand, stared into space and rolled her eyes during another speaker’s remarks. When she spoke, she excoriated the world for leaving West Africa vulnerable to the largest Ebola epidemic in history. “We’re failing, guys,” she said.

Joanne Liu visiting an MSF trauma centre in Kunduz, Afghanistan.

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New Thinking on Countering Outbreaks

                                                        

If Ebola has taught us anything, it is that there is room for innovation in the way we respond to outbreaks.

medium.com - by Paul G. Allen - April 30, 2015

It has been more than a year since we began tackling this latest epidemic and, while significant progress has been made, there are still challenges to be overcome and gaps to be filled. . . .

. . . Just last week, I partnered with Skoll Global Threats Fund and USAID to host the Ebola Innovation Summit — an interactive event, designed to bring new tools, people, ways of thinking and ultimately innovations to the forefront.

The event drew a diverse group of people from around the world — from the tech and private sectors to nonprofits, government and academia. The collective commitment of this group is a great example for how we should collaborate to tackle global problems like Ebola.

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Ban to convene international Ebola recovery conference in New York

UN NEWS CENTRE                                                                                June 2, 2015

To help mobilize needed resources “in the last mile of the response” against the Ebola outbreak and to start the affected West African countries on the path of early recovery, United Nations Secretary-General Ban Ki-moon today announced that he will convene an international conference next month.
In Sierra Leone, local health workers plan for the day ahead, as they continue their vigilance against Ebola. Photo: WHO/S. Aranda

“All of your investments, all of the sacrifices and lives lost, and all of the risks that the relief workers took would be squandered if the outbreak recurs,” Mr. Ban cautioned in his remarks to an informal plenary of the UN General Assembly on the Organization’s Ebola response efforts.

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UNMission for Ebola Emergency Response (UNMEER) External Situation Report 1 June 2015

UNMission for Ebola Emergency Response (UNMEER) External Situation Report  June 1,2015
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Further preparedness measures taking place in Guinea Bissau, following newly confirmed Ebola
cases in adjacent border areas of Guinea
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Response efforts continue in Boké prefecture, as preparations for the forthcoming sensitisation and
early Ebola case search campaign progress in Dubréka.
...
UNMEER Comment: In Kamsar (Boké prefecture, Guinea)...: the number of burial teams may still
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