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First GSK Ebola vaccine shipment due to arrive in Liberia

REUTERS by Kate Kelland                                     Jan. 23, 2015

LONDON-- The first batch of GlaxoSmithKline's experimental Ebola vaccine has been shipped to West Africa and is expected to arrive in Liberia later on Friday, the British drugmaker said.

The shipment, of an initial 300 vials of the vaccine, will be the first to arrive in one of the three main Ebola-affected African countries, GSK said in a statement.

It will be used in the first large-scale vaccine trials in coming weeks, in which healthcare workers helping to care for Ebola patients will be among the first to get it...

The vaccine, co-developed by the National Institutes of Health in the United States and Okairos, a biotechnology firm acquired by GSK in 2013, is currently being tested in five small phase I safety trials in Britain, the United States, Switzerland and Mali involving around 200 healthy volunteers in total.

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http://uk.reuters.com/article/2015/01/23/uk-health-ebola-gsk-idUKKBN0KW0DU20150123

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Ebola ebbing in West Africa but vigilance needed: WHO

REUTERS by Stephanie Nebehay                                                                        Jan. 22, 2015

GENEVA (Reuters) - The Ebola epidemic in West Africa appears to be ebbing, with fewer than 150 cases reported in the past week, but efforts must be pursued to stamp out the deadly disease, the World Health Organization (WHO) said on Thursday.

Sierra Leone remains hardest-hit, accounting for 117 of the 145 new confirmed cases, against 184 there the previous week and 248 the week before that, the WHO said in its latest update.

"Case incidence continues to fall in Guinea, Liberia, and Sierra Leone," the United Nations agency said, adding that disease surveillance was being stepped up in border districts of Guinea-Bissau, Ivory Coast, Mali and Senegal....

The WHO's Emergency Committee on Ebola said on Wednesday that passengers should still be screened on leaving Guinea, Liberia and Sierra Leone for temperature or other signs of infection.

The independent experts said in a statement that "more than 40 countries have implemented additional measures, such as quarantine of returning travellers and refusal of entry. Such measures are impeding the recruitment and return of international responders.

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Chimps and gorillas desperately need Ebola vaccine too – virus has wiped out a third of them

THE CONVERSATION  by Meera Inglis (affiliated with the Green Party of England)     Jan. 20, 2015

                                                  Ebola has wiped out a third of the world’s gorillas.

THE CONVERSATION  by Meera Inglis (affiliated with the Green Party of England)                       Jan. 20, 2015

There is a side to the Ebola crisis that, perhaps understandably, has received little media attention: the threat it poses to our nearest cousins, the great apes of Africa. At this moment in time Ebola is the single greatest threat to the survival of gorillas and chimpanzees.

The virus is even more deadly for other great apes as it is for humans, with mortality rates approximately 95% for gorillas and 77% for chimpanzees (Pan troglodytes). Current estimates suggest a third of the world’s gorillas and chimpanzees have died from Ebola since the 1990s.

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Ebola mutations could make some drugs ineffective

BALTIMORE SUN     by Scott Dance                                                   Jan. 20, 2015

In the year since Ebola began spreading across West Africa, the virus has mutated in more than 600 ways that change it slightly from versions studied in labs and used to develop treatments, according to researchers at Fort Detrick. And 10 of the mutations could make some drugs used to treat the virus ineffective, they wrote in research published Tuesday.

The "genomic drift," as the scientists called it, could make agents similar to the experimental drug ZMapp unable to bind to the virus anymore.

While the changes affect only a tiny fraction of Ebola's genome, they offer new lessons about the virus that might not have been learned because of the wide scope of the outbreak, larger than all others combined
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http://www.baltimoresun.com/health/bs-hs-ebola-mutation-20150120-story.html

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UN: African Countries 'Vital' in Fight Against Ebola

VOICE OF AMERICA    by  Jennifer Lazuta                                                         Jan. 20, 2015
DAKAR, SENEGAL—Sub-Saharan African countries have made relatively small, but “vitally important,” contributions towards the fight against Ebola according to the U.N. Mission for Ebola Emergency Response. This includes sending much-needed health care workers and medical supplies, as well as dedicating already-limited resources toward prevention and surveillance measures within their own borders to stop the further spread of the disease.

Health workers accompany a nine-year-old who contracted the Ebola virus to a Monrovia treatment center.

More than 850 doctors and nurses from African countries have been deployed to Guinea, Liberia and Sierra Leone to help bring an end to West Africa’s Ebola outbreak, which has killed more than 8,500 people since it began nearly a year ago.  

African countries also have collectively donated tens of millions of dollars in financial aid and material resources.

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Davos: Western world ‘vulnerable’ to epidemics, warns Ebola expert

BBC  by Joe Miller                                                                                                    Jan. 21, 2015
DAVOS Switzerland -- The Western world is "vulnerable" to epidemics such as Ebola, and must invest more in researching vaccines, a leading scientist has warned.

Prof Peter Piot told the BBC that developed nations would be in "deep trouble" if they failed to adequately prepare for another outbreak.

Speaking at the World Economic Forum, in Davos, he urged global leaders to take a "long-term view". Public health policies must "transcend politics and borders", he said.

The threat of Ebola, and other infectious diseases such as influenza and Sars, are set to be discussed in Switzerland this week, as politicians and business leaders from around the globe gather for the annual WEF.

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http://www.bbc.com/news/business-30907630

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Ebola Fight Needs $1 Billion More as Outbreak Wanes

BLOOMBERG  By Simeon Bennett and Makiko Kitamura                                                       Jan. 21, 2015
(Two links. Scroll below.)

Ebola remains a global health emergency, the United Nations said today as it sought another $1 billion in donations to fight the deadly outbreak in West Africa.

More money is needed for the World Health Organization, Unicef and the World Food Programme, David Nabarro, the UN’s special envoy for Ebola, said at a briefing today at the World Economic Forum annual meeting in Davos, Switzerland.

“We can’t let down our guard,” Tom Frieden, director of the U.S. Centers for Disease Control and Prevention, said in a Bloomberg Television interview at Davos. “We have to get over the finish line and then learn from this experience to build better systems so that it doesn’t get out of control the next time” an infectious disease epidemic occurs.

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UN Ebola Chief Calls for Final Funding Push to Defeat Virus in West Africa

      

Ebola treatment centres have often not been completed until the virus has passed its peak.
Photograph: Francisco Leong/AFP/Getty Images

UN’s lead Ebola co-ordinator en route to Davos says last third of the $1.5bn pledged to tackle disease needs to be paid in order to end the outbreak

theguardian.com - by Sarah Boseley - January 20, 2015

Half a billion dollars of aid pledged to end the Ebola outbreak in west Africa still hasn’t been paid, according to the UN’s response co-ordinator.

Dr David Nabarro, in London and on his way to Davos to discuss progress against Ebola and future plans, said about two-thirds of the promised $1.5bn had been paid so far. “This last third is the most precious money but probably the most difficult money,” he told the Guardian. “My focus over the next few days here and in Davos is trying to ensure we have enough money to enable the task to be completed.

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Splinter Ebola Outbreaks Hinder Fight Against Virus: UN

BLOOMBERG      by  Jason Gale                                                                 Jan. 19, 2015

West Africa’s Ebola epidemic has morphed into several micro-outbreaks of varying intensity and with the potential to reignite more widespread contagion, a United Nations official said.

The pattern of spread has become more nuanced and complex, occurring over a wider area, David Nabarro, the UN Secretary-General’s special envoy on Ebola, said in a report by the Global Ebola Response Information Centre.

The 36-page publication, dated January 2015, outlines progress to date and changes in the global response needed to end the deadly scourge, which began in December 2013 in a remote area of Guinea, near the border with Liberia and Sierra Leone. ...

“Ending the outbreak will not be easy because the disease is being transmitted in three countries with a collective land area greater than the United Kingdom,” Nabarro said. “Success can only be achieved if communities themselves understand the nature of the outbreak and act in ways that reduce their likelihood of becoming infected.”

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U.S.-built Ebola treatment centers in Liberia are nearly empty as outbreak fades


Workers at an Ebola treatment center relax Jan. 10, 2015 in Tubmanburg, Liberia. The facility was built by the U.S. military. (Whitney Leaming/The Washington Post)

WASHINGTON POST  by Kevin Sieff                                                          Jan. 19, 2015

UBMANBURG, Liberia — Near the hillside shelter where dozens of men and women died of Ebola, a row of green U.S. military tents sit atop a vast expanse of imported gravel. The generators hum; chlorinated water churns in brand-new containers; surveillance cameras send a live feed to a large-screen television.

There’s only one thing missing from this state-of-the-art Ebola treatment center: Ebola patients.

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