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The Flu is Coming. Are We Ready for the Next Pandemic?

           

Infectious disease experts have had plenty to worry about in recent decades, including HIV/AIDS, Ebola, and Zika. But one disease scares them above all others—influenza. That’s right, the flu.

news.emory.edu - by Martha McKenzie - December 2018

Even though many people dismiss and misunderstand it—calling everything from a cold to a stomach bug “the flu”— influenza actually claims 12,000 to 56,000 lives in the U.S. every year. And that’s in a normal flu season.

Every so often, a flu pandemic emerges. That’s when a new strain appears that is so different from what has circulated before that people have no immunity to it. A hundred years ago, the 1918 H1N1 pandemic swept the globe infecting about a third of the world’s population and killing 50 million to 100 million people. Since then, there have been three more pandemics, in 1957, 1968, and 2009.

The next pandemic, say experts, is a question of when, not if. Are we ready?

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Animal Viruses: New Model Predicts Which May Spread Among Humans

CLICK HERE - STUDY - Transmissibility of emerging viral zoonoses

outbreaknewstoday.com - November 21, 2018

Researchers have developed a model that predicts which of the viruses that can jump from animals to people can also be transmitted from person to person–and are therefore possible sources of human diseases.

The study, published recently in PLOS One, identified several viruses that are not yet known to spread among humans but may have that potential, suggesting possible targets for future disease surveillance and research efforts.

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ALSO SEE RELATED ARTICLE HERE - Pub Med - Transmissibility of emerging viral zoonoses

 

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World's Vertebrate Population Dropped by an Average of 60 Percent Since 1970, WWF Says

CLICK HERE - WWF - Living Planet Report 2018: Aiming Higher

"There cannot be a healthy, happy and prosperous future for people" without biodiversity, the report warns.

nbcnews.com - by Rachel Elbaum - October 30, 2018

The population of the planet's vertebrates has dropped an average of 60 percent since 1970, according to a report by the WWF conservation organization.

The most striking decline in vertebrate population was in the tropics in South and Central America, with an 89 percent loss compared to 1970. Freshwater species have also significantly fallen — down 83 percent in that period.

The Living Planet Index, provided by the Zoological Society of London (ZSL) and included in the WWF Living Planet 2018 report, tracked the population of mammals, birds, fish, reptiles and amphibians around the world between 1970 and 2014, the latest year for which data was available.

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Outbreak of African Swine Fever Threatens to Spread from China to Other Asian Countries

           

There is no effective vaccine to protect swine from the disease.

FAO urges regional collaboration including stronger monitoring and preparedness measures

fao.org - August 28, 2018

The rapid onset of African Swine Fever (ASF) in China, and its detection in areas more than one thousand kilometres apart within the country, could mean the deadly pig virus may spread to other Asian countries anytime, the UN's Food and Agriculture Organization (FAO) warned today. 

There is no effective vaccine to protect swine from the disease. And, while the disease poses no direct threat to human health, outbreaks can be devastating with the most virulent forms lethal in 100 percent of infected animals.

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ALSO SEE RELATED ARTICLE HERE - 'It’s not if, it’s when': the deadly pig disease spreading around the world

 

 

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China Has Withheld Samples of a Dangerous Flu Virus

           

Health workers attending to an H7N9 avian flu patient in Wuhan, China, in 2017. CreditCreditAgence France-Presse -- Getty Images

CLICK HERE - WHO - Pandemic influenza preparedness Framework for the sharing of influenza viruses and access to vaccines and other benefits (68 page .PDF document)

Despite an international agreement, U.S. health authorities still have not received H7N9 avian flu specimens from their Chinese counterparts.

nytimes.com - by Emily Baumgaertner - August 27, 2018

For over a year, the Chinese government has withheld lab samples of a rapidly evolving influenza virus from the United States — specimens needed to develop vaccines and treatments, according to federal health officials.

Despite persistent requests from government officials and research institutions, China has not provided samples of the dangerous virus, a type of bird flu called H7N9. In the past, such exchanges have been mostly routine under rules established by the World Health Organization.

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Ticks on Migratory Birds Found to Carry Newly Discovered Hemorrhagic Fever Virus

           

Credit: Tove Hoffman

CLICK HERE - STUDY - CDC - EID - Alkhurma Hemorrhagic Fever Virus RNA in Hyalomma rufipes Ticks Infesting Migratory Birds, Europe and Asia Minor

uu.se - Press Release - June 1, 2018

In a new study, researchers at Uppsala University and other institutions have identified genetic material from the recently identified Alkhurma hemorrhagic fever virus in the tick species Hyalomma rufipes. The discovery was made after thousands of ticks were collected from migratory birds captured in the Mediterranean basin. The results indicate that birds could contribute to spreading the virus to new geographical areas.

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Beware 'Disease X': The Mystery Killer Keeping Scientists Awake at Night

CLICK HERE - WHO - R&D Blueprint - List of Blueprint priority diseases

telegraph.co.uk - by Alanna Shaikh - March 10, 2018

Over two days in early February, the World Health Organisation (WHO) convened an expert committee at its Geneva headquarters to consider the unthinkable.

The goal was to identify pathogens with the potential to spread and kill millions but for which there are currently no, or insufficient, countermeasures available . . . 

 . . . In addition to eight frightening but familiar diseases including Ebola, Zika, and Severe Acute Respiratory Syndrome (SARS), the list included a ninth global threat: Disease X.

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ALSO SEE RELATED ARTICLE HERE - Mysterious 'Disease X' Could Be The Next Deadly Global Epidemic, WHO Warns

 

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Chinese Scientists Find How Bats Carry Viruses Without Getting Sick

xinhuanet.com - Editor: Liu - February 23, 2018

CLICK HERE - Dampened STING-Dependent Interferon Activation in Bats

WASHINGTON, Feb. 22 (Xinhua) -- Chinese scientists have identified the secret of bats that harbor highly pathogenic viruses like Ebola, Marburg and SARS coronavirus but do not show clinical signs of disease.

In a paper published on Thursday in the journal Cell Host & Microbe, scientists at the Wuhan Institute of Virology in China find that in bats, an antiviral immune pathway called the STING-interferon pathway is dampened, so bats can maintain just enough defense against illness without triggering a heightened immune reaction.

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BRIEF: The Virome Project Aims to Prepare Before the Next Pandemic

           

Ebola virus budding from surface of cells, from a scanning electron micrograph.  Image credits: NIAID

CLICK HERE - The Global Virome Project

insidescience.org - by Benjamin Plackett - February 22, 2018

 . . . In an article published in Science magazine today, Daszak and a group of like-minded scientists described a new initiative, called the Virome project, that would identify and catalogue hundreds of thousands of yet-to-be-discovered viruses found in wild animals.

The team estimates that there are about 1.6 million undiscovered virus types and that somewhere between 631,000-827,000 could potentially spill over into humans. The viruses are found mostly in wild mammals.

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China Confirms First Ever Human Case of H7N4 Bird Flu

           

China has confirmed first ever human case of H7N4 bird flu Photograph: Kin Cheung/AP

CLICK HERE - The Government of Hong Kong Special Administrative Region - Press Release

A 68-year-old patient from Jiangsu province, who has since recovered, developed symptoms on Christmas Day and was admitted to hospital

theguardian.com - by Tom Phillips - February 15, 2018

A woman from eastern China has been confirmed as the first ever human case of H7N4 bird flu, according to Chinese authorities . . .

 . . . The 68-year-old patient from Jiangsu province, who has since recovered, developed symptoms on 25 December, was admitted to hospital for treatment on 1 January and was released on 22 January. 

“She had contact with live poultry before the onset of symptoms,” Hong Kong’s centre for health protection (CHP) said in an alert on Wednesday evening. “According to a report from the Chinese centre for disease control and prevention, upon analysis, the genes of the virus were determined to be of avian origin.”

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