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Large study shows safety of COVID mRNA vaccines in young children

Messenger RNA vaccines for COVID-19 pose little risk to young children, with no myocarditis (inflammation of heart muscle) or pericarditis (inflammation around the heart) observed in vaccine recipients age 0 to 4. The reassuring findings were published today in Pediatrics.

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Global COVID-19 activity remains mixed, although up in Western Pacific and Africa

Cases and death continued to decline globally over the past 4 weeks, with hot spots reported in a few countries as XBB Omicron variant proportions continue to shift, the World Health Organization (WHO) said today in its latest weekly update.

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Activity is up, however, in two regions: the Western Pacific by 10% and Africa by 3%. Deaths declined or were stable in all six regions.

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Night shift work, binge drinking linked to increased COVID risk in nurses --study

Working the night shift or binge drinking may double the risk of COVID-19 infection, according to a study of nurses published this week in Alcohol: Clinical and Experimental Research. Poor sleep quality and binge drinking have been associated with COVID-19 infections, likely because both promote a pro-inflammatory state.

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Bivalent COVID vaccine efficacy at 6 months drops 24% against hospitalization, strong against death --CDC study

Estimated bivalent (two-strain) COVID-19 mRNA vaccine effectiveness (VE) against hospitalization dropped from 62% 1 week after receipt to 24% at 4 to 6 months in adults with healthy immune systems, but protection against severe outcomes was sustained, according to a US Centers for Disease Control and Prevention (CDC) study.

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Antibodies spiked then waned after Pfizer, Moderna COVID vaccines, but J&J response was opposite

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One month after COVID-19 vaccination, compared with J&J recipients, nAB levels were 51 times higher among Moderna recipients and 21 times higher among Pfizer recipients. At 6 months, however, J&J vaccinees produced the same antibody response as that of Moderna and significantly higher concentrations than those of Pfizer.

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Paxlovid slashed risk of COVID hospital stay in unvaccinated patients -- Canadian study

The antiviral drug Paxlovid was tied to a 96% lower relative risk (RR) of COVID-19 hospitalization among high-risk outpatients who didn't complete a primary vaccination series but didn't benefit those who had received at least two doses amid the SARS-CoV-2 Omicron variant, according to a real-world study published yesterday in Clinical Infectious Diseases.

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