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The mission of the Global Health Working Group is to explore and improve current and emerging states of health and human security worldwide.

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Link Removal for the Control of Stochastically Evolving Epidemics Over Networks: A Comparison of Approaches

submitted by George Hurlburt

CLICK HERE - Link Removal for the Control of Stochastically Evolving Epidemics Over Networks: A Comparison of Approaches

sciencedirect.com - Elsevier - February 16, 2015 - doi:10.1016/j.jtbi.2015.02.005

Highlights

• Disease control efforts are often constrained by limited resources.
• Limited resources can be used more effectively by leveraging network information.
• We compare four link removal algorithms to prevent disease spread under a budget.
• Optimal quarantining performs best for large budgets and structured networks.
• Knowing where an outbreak begins is most valuable at moderate budget levels.

Abstract

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6 Challenges to Stamping Out Ebola

Despite a recent sharp drop in the overall number of Ebola cases, the situation remains precarious in West Africa

NATURE MAGAZINE  by Declan Butler                                                                    Feb. 24, 2015
More than a year since the start of one of the worst public health crises in recent history, Ebola cases have been tumbling in West Africa. But the epidemic is far from over: the risk of flare ups and further geographical spread will remain until there are no new cases.

The ease in case numbers means that public-health countermeasures and resources can be shifted in many places, from curbing runaway outbreaks to aggressively targeting the remaining, often smaller outbreaks....

At the same time, there is a danger of complacency. Reducing the number of cases to zero demands identifying and breaking all new chains of transmission, a task that still faces major obstacles—not least the fast approaching rainy season.

Highlighting the precariousness of the current situation, on February 20, the officials leading the United Nations' Ebola response efforts warned that the gains of the past few months risked unravelling.

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Nowhere to run: North Korea, citing Ebola concerns, bars foreigners from Pyongyang marathon

ASSOCIATED PRESS  By ERIC TALMADGE                                                                                   Feb. 23, 2015

TOKYO  — Further restricting travel to the already isolated country, North Korea barred foreigners from one of its most popular tourist events — the annual Pyongyang marathon — because of concerns over the Ebola virus, travel agencies said Monday.

While no cases of Ebola have been reported anywhere near North Korea, the country shut out foreign tourists in October with some of the strictest Ebola regulations in the world. North Korean media have suggested Ebola was created by the U.S. military as a biological weapon.

Nick Bonner, co-founder of Beijing-based Koryo Tours, said he did not think the decision reflected any deeper problems in the North's secretive and often enigmatic government, though the news comes amid reports leader Kim Jong Un has called for increased combat readiness and, at a meeting of senior party and military leaders, described tensions on the peninsula as graver than ever before.

Read complete story.

http://www.usnews.com/news/world/articles/2015/02/23/north-korea-bars-foreigners-from-pyongyang-marathon

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2 leading Ebola vaccines appear safe, WHO says

ASSOCIATED PRESS by Maria Cheng                                                                                 Feb. 23, 2015

LONDON – The World Health Organization says the two leading Ebola vaccines appear safe and will soon be tested in healthy volunteers in West Africa.

After an expert meeting this week, WHO said there is now enough information to conclude that the two most advanced Ebola vaccines — one made by GlaxoSmithKline and the other licensed by Merck and NewLink — have "an acceptable safety profile."

In a press briefing Friday, Dr. Marie-Paule Kieny, who heads WHO's Ebola vaccine efforts, said "the cupboard (for Ebola vaccines) is filling up rapidly."

She said further trials in healthy people in West Africa, including health workers, are scheduled to start soon. Kieny added several other vaccines were being developed in the U.S., Russia and elsewhere.

Read complete story.
http://www.baxterbulletin.com/story/life/health/2015/02/23/leading-ebola-vaccines-appear-safe-says/23901829/

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Limited Promise in early results from Ebola drug trial

AFP                                                                                                                     Feb. 23, 2015
Los Angeles  - Early results from an Ebola trial using the experimental drug Avigan (favipiravir) showed Monday it was somewhat effective at saving lives if given early in the illness, but not later.

Early results from an Ebola trial using the experimental drug Avigan (favipiravir) show it is somewhat effective at saving lives if given early in the illness (AFP Photo/George Frey)

The antiviral treatment is being developed by the Japanese company Toyama Chemical, and has been shown safe and effective against some other viruses including influenza, West Nile and yellow fever.

An ongoing clinical trial in Guinea is testing the drug's use in patients with the Ebola virus, which causes severe vomiting, diarrhea and sometimes fatal bleeding.

Results from only 80 people are available so far, but they show that among those who received the drug early in their illness, 15 percent died of Ebola.

Read complete story.

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Ebola crisis: Sierra Leone orphanage quarantined

BBC            by Umaru Fofana                                        Feb. 23, 2015

FREETOWN, Sierra Leone --An orphanage run by a UK charity in Sierra Leone has been quarantined after one of its local staff was diagnosed with the deadly Ebola virus.

Augustine Baker is said to be in a stable condition at a local treatment centre after becoming ill last week....

St George Foundation orphanage co-founder Philip Dean told the BBC that 33 children and seven staff were now in isolation.

The BBC's Umaru Fofana in the capital, Freetown, says that the quarantine at the St George Foundation orphanage is self-imposed, and is expected to last for three weeks.

Read complete story.

http://www.bbc.com/news/world-africa-31587180

                                                             St George Foundation has helped about 200 children orphaned by Ebola.

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Funding to Fight Ebola: Not Too Little, but Definitely Too Late

Center for Global Development - cgdev.org -by Karen A. Grépin and Amanda Glassman - February 4, 2015

. . . In a new paper out today in the BMJ, Karen investigated the level and speed of the international response to the Ebola outbreak and contrasted it with the appeals made by international leaders to curb the spread of the disease. Contrary to widespread belief, Karen finds that, overall, the level of donations to the response were actually robust: as of December 31st, 2,104 donors had pledged almost $3 billion towards controlling the epidemic. Notably, this is actually larger than the official appeals for upwards of $1.5 billion. In addition, the data used underestimate total donations, in particular those given by the World Bank, which mobilized at least $1 billion in financing to help support affected countries.

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Ebola in Liberia: Keeping communities safe from contaminated waste

 WHO PRESS RELEASE                                                                                              Feb. 23, 2015

Every day, every bed in an Ebola treatment unit creates approximately 300 litres of liquid waste. Managing this waste has been a challenge in the Ebola outbreak in Liberia. WHO is working with partners to ensure this waste is effectively decontaminated and no longer poses a threat to health.

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UK Ebola medics under investigation

BBC                                                                      Feb.23, 2015

Five UK Ebola nurses and doctors are under investigation by regulators, Public Health England says.

They are looking into the screening of medics who flew back to England on 28 December after treating patients in Sierra Leone.

                  Pauline Cafferkey was diagnosed with Ebola in December after volunteering work in Sierra Leone

On this flight was Scottish nurse Pauline Cafferkey - who developed Ebola - and some of her colleagues.

Questions have arisen over the health assessments and protocols that were followed.

Media reports have suggested Ms Cafferkey may have had signs of Ebola before leaving Sierra Leone but regulators have not commented on this.

http://m.bbc.com/news/health-31586074

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Interview: Liberia leader urges help in post-Ebola phase

Liberian President urges more support for recovery, to meet next week with President Obama

(Two stories. Scroll down.)

ASSOCIATED PRESS                                                                                      Feb. 22, 2015
HARJAH, United Arab Emirates — Liberia’s leader on Sunday urged the United States and other countries to keep up their support to the West African nation as it recovers from the Ebola epidemic and refocuses attention on infrastructure projects that will better position it to tackle future outbreaks of disease.

Liberian President Ellen Johnson-Sirleaf speaks to villagers about Ebola virus precautions outside Ganta, Liberia, October 7, 2014. Credit: Reuters/Daniel Flynn

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