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Guinea Resilience System

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The Guinea Resilience System working group is focused on the development of Resilience Systems in Guinea.

The mission of the Guinea Resilience System working group is to develop Resilience Systems and their nested subsystems in Guinea.

Members

Abdoulaye Drame Aboubacar Conte Anthony Boubacar Kaba Carrielaj Chisina Kapungu
Elhadj Drame Hadiatou Balde Ismael Dioubate John Wysham Kathy Gilbeaux Lancine Konate
Mamadou Diallo Mamadou Moustap... Mamadou Sylla mdmcdonald MDMcDonald_me_com mike kraft
Norea Souleymane Drame

Email address for group

guinea-resilience-system@m.resiliencesystem.org

Evaluating Ebola Therapies — The Case for RCTs

THE NEW ENGLAND JOURNAL OF MEDICINE                                                                                 Dec. 3, 2014
By Edward Cox, M.D., M.P.H., Luciana Borio, M.D., and Robert Temple, M.D.

...Studying investigational therapies for EVD presents scientific, practical, and ethical challenges. Not surprisingly, there has been substantial debate about the best and most appropriate study approaches.2,3 It is generally agreed that a trial with a concurrent control group, in which patients are randomly assigned to receive the test drug plus the best available supportive care (BASC) or to BASC alone, would be the most efficient and reliable way to evaluate the safety and effectiveness of candidate products.

 Some people in the health care community, however, have argued against such trials, urging instead use of a historical control — that is, making investigational drugs as widely available as their supply allows and then comparing mortality rates among treated patients with rates that would have been expected absent the drugs, on the basis of past experience with EVD.

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Sierra Leone widens Ebola quarantine

AFP                                                                                                          Dec. 2, 2014

FREETOWN -- Ebola-hit Sierra Leone has quarantined hundreds of thousands more citizens, it said Tuesday, sealing off a sixth district, with more than half of the country's population already under lockdown.

A nurse wearing personal protective equipment checks on a patient at the Kenama ebola treatment center run by the Red Cross Society on November 15, 2014 in Sierra Leone ©Francisco Leong (AFP/File)

Tonkolili, in the centre, was added to the growing list of districts which no one is allowed to leave or enter without special dispensation, in an effort to combat an outbreak which is spiralling out of control, with 1,400 deaths so far....

The northern districts of Port Loko and Bombali were closed off indefinitely along with the southern district of Moyamba in September -- effectively sealing in more than one million people.

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Five million children out of school in West Africa due to Ebola

REUTERS-by  Misha Hussain                                   Dec. 3, 2014

DAKAR, Senegal   - Some five million children are out of school in Guinea, Liberia and Sierra Leone because of the deadly Ebola outbreak, according to a report by the Global Business Coalition for Education.

A man walks by a mural with health instructions on treating the Ebola virus, in Monrovia, November 18, 2014. Credit: Reuters/James Giahyue

Schools and other public buildings have been closed because they are believed to increase the spread of the virus. Many are now used as holding centers for Ebola patients.

The report, co-written with A World at School, said being out of school can have a crippling impact on vulnerable children, especially girls, who are more likely to face high-risk situations as a result, including early marriage and pregnancy.

If schools are not reopened, the most vulnerable children will become trapped in a cycle of poverty with devastating consequences for their health and economic development, the report said.

Read complete story.

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Sierra Leonean in US Sends Medical Supplies Home to Combat Ebola

voanews.com - by Deborah Block - Nov 26, 2014



On Thanksgiving day in the United States, Americans give thanks for their blessings. Among them is Bobby Smith, who emigrated to here 25 years ago from Sierra Leone. To give back, three years ago Smith began a small volunteer organization, Hope for Lives in Sierra Leone, to help the disadvantaged in his homeland -- one of the poorest countries in the world. As VOA’s Deborah Block reports, he now is sending medical supplies to help combat Ebola, which continues to devastate Sierra Leone.

http://www.voanews.com/media/video/sierra-leonean-in-us-sends-medical-supplies-home-to-combat-ebola/2535979.html

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Finding the Ebola virus’ vulnerable points

Three copies of the Ebola glycoprotein (blue) with antibodies (yellow) latched on to them. Picture by Stanfordby Shalini Saxena - Nov 30 2014 - http://arstechnica.com

We know what antibodies stop it in its tracks—we now know where they attach.

The latest Ebola outbreak has dwarfed any that have occurred since the discovery of the virus in 1976; previous outbreaks have had lethality rates of up to 90 percent. Yet no vaccines or therapies are currently approved for human use, which limits our ability to treat patients and contain the outbreak. Mixtures of monoclonal antibodies (see sidebar) are a potential treatment option that has been used experimentally.

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In Liberia, Ebola Shifts From Cities To Villages

November 30, 2014 - Rachel Martin - npr.org - Copyright © 2014 NPR

Liberia has been a death zone for those exposed to the Ebola virus. NPR's Rachel Martin speaks with correspondent Kelly McEvers about what she saw on the ground, and what she will find hard to forget.

RACHEL MARTIN, HOST:

The death toll in the largest Ebola outbreak in history continues to rise in West Africa. Just this past week, the World Health Organization reported 600 new cases in the three hardest hit countries - Guinea, Sierra Leone and Liberia. Liberia had been the epicenter of the outbreak. But now the country with the largest number of victims is neighboring Sierra Leone. NPR reporters have been covering the story in both countries. NPR's Kelly McEvers is about to finish nearly two weeks in Liberia. She joins us on the line. Hi, Kelly.

Read the whole interview:

http://www.npr.org/2014/11/30/367544593/in-liberia-ebola-shifts-from-cities-to-villages

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U.N. Mission Warns That Ebola Still Poses ‘Huge’ Global Threat

A mother and child stand atop their mattresses in a classroom now used as Ebola isolation ward on Aug. 15, 2014, in Monrovia, Liberiaby Elizabeth Barber - Dec. 1, 2014 - time.com

The U.N. mission is urging that the longer the disease is allowed to storm West Africa, the more likely it is that the virus will reappear elsewhere in the world.

The head of the U.N. Ebola mission in West Africa has said there is a “huge risk” of the Ebola outbreak expanding beyond the hard-hit region.

https://time.com/3611314/u-n-ebola-global-threat-anthony-banbury-bbc/

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WHO Says Liberia, Guinea Meeting Ebola Targets

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U.S. designates 35 hospitals to treat Ebola patients

WASHINGTON POST-- By Lena H. Sun                                                                                         Dec. 2, 2014

WASHINGTON --U.S. officials have designated 35 hospitals around the country to care for Ebola patients, part of the Obama administration’s effort in the past two months to improve domestic preparedness to cope with the deadly virus that has ravaged West Africa.

 

A nurse walks down a hallway alongside a patient care room in a new custom-built bio-containment unit for potential Ebola cases at Mount Sinai Hospital, in New York. (John Minchillo/AP)

 The hospitals were chosen by state health officials and hospital executives and assessed by infection control teams from the Centers for Disease Control and Prevention to make sure they have adequate staff, equipment, training and resources “to provide the extensive treatment necessary to care for an Ebola patient,” according to a senior administration official.

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2014 Goals for Ebola Treatment May Not Be Met, U.N. Health Officials Say

NEW YORK TIMES  By Sheri Fink and  Somini Sengupta                                                       Dec. 2, 1014

GENEVA — The World Health Organization expressed doubt on Monday about achieving important United Nations benchmarks in battling Ebola, saying the year-end goals of isolating and treating all patients and safely burying all the dead would be major challenges.

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