https://www.nejm.org/doi/full/10.1056/NEJMp2034334

On the Shoulders of Giants — From Jenner’s Cowpox to mRNA Covid Vaccines

In September 2008, Katalin Karikó, Drew Weissman, and their colleagues at the University of Pennsylvania modified messenger RNA (mRNA) using nucleoside analogues. These modifications stabilized the molecule and eliminated its capacity for inducing innate immunity, thereby making mRNA a promising tool for both gene replacement and vaccination.¹ In December 2020, on the basis of safety and efficacy data generated in two large, placebo-controlled studies, the Food and Drug Administration (FDA) issued emergency use authorizations for two mRNA vaccines for the prevention of Covid-19. Clearance of this hurdle by the first mRNA vaccines represents the most recent in a series of breakthroughs in the realm of viral vaccines, each building on the last and each with a compelling record of disease prevention.

The fourth COVID-19 wave is here Cases are up 17% over last week. Sam Baker,Andrew Witherspoon Axios

The big picture: America may be at the beginning of a fourth wave in the pandemic. It will almost certainly be far less deadly than the previous three, but this persistent failure to contain the virus has real consequences, and will only make it harder to put COVID-19 behind us.

Oklahoma town eases pandemic, one restaurant meal at a time NEW YORK (AP) — In Miami, Oklahoma, restaurants and their customers are doing their part to ease pandemic heartache, one meal at a time. Cafes in and around the close-knit town in the... AP NEWS

NEW YORK (AP) — In Miami, Oklahoma, restaurants and their customers are doing their part to ease pandemic heartache, one meal at a time.

In a spring of hope, Michigan is a reminder that the Covid winter has yet to pass

Americans have entered a disconcerting phase of the pandemic.

They are awash in hopeful news: With more than 2.8 million shots on average being administered every day, the country is fast approaching universal vaccine eligibility for all adults.

And then there are problems like Michigan.

In a rural stretch of the state along the shore of Lake Huron, coronavirus outbreaks are ripping through churches, schools and restaurants. For more than a week, ambulances have taken several hourlong trips each day to rush Covid-19 patients to I.C.U.s in Detroit, Port Huron or Saginaw.

Factbox-Latest on the worldwide spread of the coronavirus The World Trade Organization said risks from the uneven roll-out of coronavirus vaccination campaigns and the possible emergence of vaccine-resistant strains clouded the outlook for the global trade in goods, while raising its growth forecast slightly. Reuters Staff U.S.

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* All health workers in Italy must have coronavirus jabs, the government said, in a potentially controversial move aimed at protecting vulnerable patients and pushing back against ‘no-vax’ sentiment.