NEW YORK TIMES --by Gardiner Harris                                                                                 Dec. 4, 2014

AMRAVATI, India — A deadly epidemic that could have global implications is quietly sweeping India, and among its many victims are tens of thousands of newborns dying because once-miraculous cures no longer work.

Everybody and his uncle, it seems, has an idea of something that might work to cure people infected with the deadly virus

 SCIENTIFIC AMERICAN    By Helen Branswell                        Dec. 4, 2014

When it comes to treatments for Ebola, there has been a nearly four-decade-long drought. Nothing in the medical arsenal attacks the virus directly....

 

 

 

Dr. John M. Dye, Jr., U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID) Viral Immunology branch chief, works in a laboratory at the USAMRIID headquarters in Frederick, Maryland. Dr. Dye is leading a team that is conducting a study with nonhuman primates involving the experimental drug ZMapp, an experimental treatment for Ebola patients. Credit: CDC

 

MILITARYNEWS.COM  by Richard Sisk                            Dec. 3, 2014

The U.S. military was scaling back its efforts against Ebola in Liberia amid encouraging signs of progress against the epidemic, Army Gen. David Rodriguez said Wednesday.

 

U.S. personnel construct the Monrovia Medical Unit site in Monrovia, Liberia. The MMU is being constructed in the event any medical workers in the area catch Ebola while assisting in Operation United Assistance. Craig Philbrick/Army

The military initially planned to construct 17 treatment centers of 100 beds each in Liberia, but will now set up 10 centers for virus victims. The first three centers will have 100 beds, but the remaining seven will have 50 beds, Rodriguez, head of U.S. Africa Command, said at a Pentagon briefing.

Rodriguez also said the military was looking at possibly easing the 30-day quarantine period for troops returning from West Africa. However, he stressed that no decisions had been made.

      

November 21, 2014 - A family behind a bright orange quarantine rope learns of the death of a family member.
Nikki Kahn/The Washington Post

WASHINGTON POST--by Kevin Sieff                                                                 Dec. 4, 2014
KOINADUGU, Sierra Leone --
...Six months after the world’s largest Ebola outbreak began, experts say one of their biggest challenges is persuading people to trust the medical system. Families still hide suspected Ebola victimsor refuse to take them to health facilities. The problem exists in Liberia, but some foreign health officials say it’s even more daunting in Sierra Leone, where the transmission rate continues to climb even as it declines in the neighboring country.

In rural areas like Koinadugu, a district bordering Guinea, the problem is especially severe. There is no electricity or running water, let alone a modern hospital. Medicine usually means local herbs, generic malaria pills or the advice of a local healer. People whisper that disinfectant spreads the disease rather than kills it.

BLOOMBERG--By Andrew Pollack and Doni Bloomfield                                                                  Dec.4, 2014

ATLANTA-- An American health worker who may have been exposed to the Ebola virus arrived at an Atlanta hospital today for possible treatment after being evacuated by air from West Africa, where the outbreak is at its worst.

The health worker, who hasn’t been publicly identified, was admitted this morning at Emory University Hospital, which has successfully treated four other Ebola patients, the hospital said in an e-mail.

“Emory cannot share more details out of respect for patient privacy and in accordance with the patient’s wishes,” the hospital said. Phoenix Air, a medical charter company, flew the patient from West Africa, according to the statement. Earlier this week, Emory was named one of 35 U.S. hospitals designated to treat Ebola patients.

Emory didn’t say in what country the health worker may have been exposed.
Read complete story.

http://www.bloomberg.com/news/2014-12-04/health-care-worker-who-may-have-ebola-headed-to-u-s-.html

VOICE OF AMERICA                                      Dec. 3, 2014

New data shows the Ebola outbreak intensifying in Sierra Leone, even as it stabilizes or drops off in other West African countries.   (Scroll down for link to WHO roadmap.)

The World Health Organization says Sierra Leone reported 537 new confirmed cases in the week ending November 30, a jump of more than 150 over the week before.  

In its latest update Wednesday, the WHO says "transmission remains persistent and intense across the country with the exception of the south."  The worst affected area was the capital, Freetown, where more than 200 new cases were reported.  

According to the WHO, the number of Ebola cases worldwide is more than 17,000, with all but a few dozen in Sierra Leone, Guinea and Liberia.  The overall death toll is up to 6,070.

Read complete story
http://www.voanews.com/content/ebola-spreading-faster-in-sierra-leone/2544743.html?utm_source=December+4+2014+EN&utm_campaign=12%2F4%2F2014&utm_medium=email

THE NEW ENGLAND JOURNAL OF MEDICINE                                                                                 Dec. 3, 2014
By Edward Cox, M.D., M.P.H., Luciana Borio, M.D., and Robert Temple, M.D.

...Studying investigational therapies for EVD presents scientific, practical, and ethical challenges. Not surprisingly, there has been substantial debate about the best and most appropriate study approaches.2,3 It is generally agreed that a trial with a concurrent control group, in which patients are randomly assigned to receive the test drug plus the best available supportive care (BASC) or to BASC alone, would be the most efficient and reliable way to evaluate the safety and effectiveness of candidate products.

 Some people in the health care community, however, have argued against such trials, urging instead use of a historical control — that is, making investigational drugs as widely available as their supply allows and then comparing mortality rates among treated patients with rates that would have been expected absent the drugs, on the basis of past experience with EVD.

AFP                                                                                                                     Dec. 3, 2014

FREETOWN --World Bank chief Jim Yong Kim announced a $160 million two-year economic recovery plan on Wednesday to help impoverished Sierra Leone battle the worst Ebola outbreak on record.

Kim said after a closed-door meeting with President Ernest Bai Koroma in Freetown the cash would go towards regional operations centres and emergency response teams in the hard-hit west and north of the country.

The aid would also focus on the country's floundering farming sector and rural job creation, he told reporters...

Kim flew to Conakry later on Wednesday, where he was expected to meet government officials and health experts.
Read complete story
http://www.straitstimes.com/news/world/more-world-stories/story/world-bank-announces-200-million-ebola-hit-sierra-leone-20141204

AFP                                                                                                          Dec. 2, 2014

FREETOWN -- Ebola-hit Sierra Leone has quarantined hundreds of thousands more citizens, it said Tuesday, sealing off a sixth district, with more than half of the country's population already under lockdown.

A nurse wearing personal protective equipment checks on a patient at the Kenama ebola treatment center run by the Red Cross Society on November 15, 2014 in Sierra Leone ©Francisco Leong (AFP/File)

Tonkolili, in the centre, was added to the growing list of districts which no one is allowed to leave or enter without special dispensation, in an effort to combat an outbreak which is spiralling out of control, with 1,400 deaths so far....

The northern districts of Port Loko and Bombali were closed off indefinitely along with the southern district of Moyamba in September -- effectively sealing in more than one million people.

INSTITUTE FOR SECURITY STUDIES                                                                                Dec. 2, 2014

Morocco’s refusal to host the Africa Cup of Nations (Afcon) from 17 January to 8 February next year, due to fears of Ebola,has sparked a furore among soccer lovers across the continent.

The North African kingdom has since become the target of some of the most aggressive xenophobia from fellow Africans, notably on social media. ‘Morocco is scared of outsiders,’ ‘Morocco is not an African country,’ are some of the insults that have been directed at the country in the wake of its decision.

... The competition has now been moved to Equatorial Guinea, co-host of the 2012 Afcon with Gabon. This decision has huge financial and political implications. Morocco has also been barred from participating in the 2015 Afcon, and risks more sanctions for its national team and Moroccan clubs.

REUTERS-by  Misha Hussain                                   Dec. 3, 2014

DAKAR, Senegal   - Some five million children are out of school in Guinea, Liberia and Sierra Leone because of the deadly Ebola outbreak, according to a report by the Global Business Coalition for Education.

A man walks by a mural with health instructions on treating the Ebola virus, in Monrovia, November 18, 2014. Credit: Reuters/James Giahyue

Schools and other public buildings have been closed because they are believed to increase the spread of the virus. Many are now used as holding centers for Ebola patients.

The report, co-written with A World at School, said being out of school can have a crippling impact on vulnerable children, especially girls, who are more likely to face high-risk situations as a result, including early marriage and pregnancy.

If schools are not reopened, the most vulnerable children will become trapped in a cycle of poverty with devastating consequences for their health and economic development, the report said.

Read complete story.

                                     

100resilientcities.org - by Michael Berkowitz - December 2, 2014

Today we proudly announce the second group of cities selected to join 100 Resilient Cities – cities who have demonstrated a commitment to building their own capacities to navigate the shocks and stresses of an increasingly complex 21st Century.

During the our first 18 months, we've seen our first cohort of cities mature, appoint chief resilience officers, and embark on their own resilience strategy processes. No doubt this momentum contributed to the immense response we saw to the second round of the 100 Resilient Cities Challenge has been enormous, with 331 exceptional applications from cities around the world, submitted in seven languages.

voanews.com - by Deborah Block - Nov 26, 2014



On Thanksgiving day in the United States, Americans give thanks for their blessings. Among them is Bobby Smith, who emigrated to here 25 years ago from Sierra Leone. To give back, three years ago Smith began a small volunteer organization, Hope for Lives in Sierra Leone, to help the disadvantaged in his homeland -- one of the poorest countries in the world. As VOA’s Deborah Block reports, he now is sending medical supplies to help combat Ebola, which continues to devastate Sierra Leone.

http://www.voanews.com/media/video/sierra-leonean-in-us-sends-medical-supplies-home-to-combat-ebola/2535979.html

by Shalini Saxena - Nov 30 2014 - http://arstechnica.com

We know what antibodies stop it in its tracks—we now know where they attach.

The latest Ebola outbreak has dwarfed any that have occurred since the discovery of the virus in 1976; previous outbreaks have had lethality rates of up to 90 percent. Yet no vaccines or therapies are currently approved for human use, which limits our ability to treat patients and contain the outbreak. Mixtures of monoclonal antibodies (see sidebar) are a potential treatment option that has been used experimentally.

by Elizabeth Barber - Dec. 1, 2014 - time.com

The U.N. mission is urging that the longer the disease is allowed to storm West Africa, the more likely it is that the virus will reappear elsewhere in the world.

The head of the U.N. Ebola mission in West Africa has said there is a “huge risk” of the Ebola outbreak expanding beyond the hard-hit region.

https://time.com/3611314/u-n-ebola-global-threat-anthony-banbury-bbc/