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Analysis: Overview of the AstraZeneca vaccine and clots issue --AP

LONDON (AP) — German officials have decided to limit the use of AstraZeneca’s coronavirus vaccine in people under 60 after more unusual blood clots were reported in a small number of people who received the shots.

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New statement: AstraZeneca COVID-19 vaccine 76% effective in updated U.S. trial results

After results are questioned, AstraZeneca says complete data shows its vaccine is still highly effective.

https://www.nytimes.com/live/2021/03/24/world/covid-vaccine-coronavirus-cases#after-results-are-questioned-astrazeneca-says-complete-data-shows-its-vaccine-is-still-highly-effective

AstraZeneca reiterated on Wednesday that its Covid-19 vaccine was very effective at preventing the disease, based on more recent data than was included when the company announced the interim results of its U.S. clinical trial on Monday.

The company said in a news release that its vaccine was 76 percent effective at preventing Covid-19. That is slightly lower than the efficacy number that the company announced earlier this week.

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U.S. health officials and an oversight board accused AstraZeneca of presenting potentially misleading information

Federal health officials and an independent oversight board accused AstraZeneca of presenting the world with potentially misleading information about the effectiveness of the company’s Covid-19 vaccine, an extraordinary blow to the credibility of a company whose product has been seen as critical to the global fight against the pandemic.

In a two-page letter to AstraZeneca and federal authorities on Monday, an independent panel of medical experts that was helping oversee the vaccine’s clinical trial in the United States said the company had essentially cherry-picked data that was “most favorable for the study as opposed to the most recent and most complete.”

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AstraZeneca commits to releasing more complete vaccine data after concerns from NIH

 

https://news.yahoo.com/astrazeneca-commits-releasing-more-complete-122835190.html

AstraZeneca acknowledged on Tuesday morning that a press release about its U.S. coronavirus vaccine trial was based on data through Feb. 17, and promised to release more complete results that are "consistent with" the interim data within the next 48 hours.

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WHO statement says the benefit of AstraZenca vaccine outweighs risk and recomends continuation

WHO statement on AstraZeneca COVID-19 vaccine safety signals

Some countries in the European Union have temporarily suspended use of the AstraZeneca COVID-19 vaccine as a precautionary measure based on reports of rare blood coagulation disorders in persons who had received the vaccine. Other countries in the EU – having considered the same information - have decided to continue using the vaccine in their immunization programmes. 

Vaccination against COVID-19 will not reduce illness or deaths from other causes. Thromboembolic events are known to occur frequently. Venous thromboembolism is the third most common cardiovascular disease globally. 

In extensive vaccination campaigns, it is routine for countries to signal potential adverse events following immunization. This does not necessarily mean that the events are linked to vaccination itself, but it is good practice to investigate them. It also shows that the surveillance system works and that effective controls are in place. 

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