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WHO Continues Zika Emergency Amid Virus Spread, Unanswered Questions

cidrap.umn.edu - by Lisa Schnirring  - September 2, 2016

WHO panel cites virus spread, research gaps
CLICK HERE - WHO - Fourth meeting of the Emergency Committee under the International Health Regulations (2005) regarding microcephaly, other neurological disorders and Zika virus 

CDC funds for microcephaly, birth defects
CLICK HERE - CDC awards $2.4 million to five jurisdictions to fight Zika

The World Health Organization (WHO) announced today that its Zika emergency committee, which met yesterday, has recommended keeping the public health emergency in place, as the US Centers for Disease Control and Prevention (CDC) announced $2.4 million in funding to help five of the nation's most populated cities detect and manage Zika-related birth defects.

CDC-Colombia effort, Singapore cases, brain cell infection
In other new Zika developments, the CDC announced a formal research collaboration with Colombia, Singapore reported more Zika cases, and researchers revealed possible differences in brain cell infections between the two Zika lineages.

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Study Finds Increase in Temporary Paralysis Accompanied Zika Outbreaks

           

Zulay Balza, right, recovering from Guillain-Barre syndrome in February at a hospital in Colombia. Ms. Balza did not show symptoms of the Zika virus; only one in five infected people do. Credit Ricardo Mazalan/Associated Press

CLICK HERE - NEJM - Zika Virus and the Guillain–Barré Syndrome — Case Series from Seven Countries

nytimes.com - by Catherine Saint Louis - August 31, 2016

In seven countries that recently experienced Zika outbreaks, there were also sharp increases in the numbers of people suffering from a form of temporary paralysis, researchers reported Wednesday.

The analysis, published online in The New England Journal of Medicine, adds to substantial evidence that Zika infections — even asymptomatic ones — may bring on a paralysis called Guillain-Barré syndrome.

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Ebola Virus Persists in Semen Far Longer Than Thought, Study Finds

statnews.com - by Helen Branswell - August 30, 2016

CLICK HERE - The Lancet Global Health - Prevention of sexual transmission of Ebola in Liberia through a national semen testing and counselling programme for survivors: an analysis of Ebola virus RNA results and behavioural data

The Ebola virus can hide itself in the testicles of men who’ve survived the disease for far longer than had been previously thought, a new study suggests.

In fact, the research reports on a man who was still emitting fragments of Ebola viruses in his semen 565 days after he became ill — or 18 months. . . .

. . . suggesting it may be due to age-related changes in the immune system.

. . . The work, published Tuesday in the journal Lancet Global Health, was done by scientists from the Liberian Ministry of Health, the Centers for Disease Control and Prevention, and the World Health Organization. . . .

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FSU Research Team Makes Zika Drug Breakthrough

submitted by Albert Gomez

           

Doctoral students Emily Lee, Yichen Cheng and Sarah Ogden played a key role in conducting Zika research in Professor Hengli Tang’s laboratory.

CLICK HERE - RESEARCH - Nature Medicine - Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen

news.fsu.edu - by Kathleen Haughney - August 29, 2016

A team of researchers from Florida State University, Johns Hopkins University and the National Institutes of Health has found existing drug compounds that can both stop Zika from replicating in the body and from damaging the crucial fetal brain cells that lead to birth defects in newborns.

One of the drugs is already on the market as a treatment for tapeworm. . . .

. . . Their work is outlined in an article published Monday by Nature Medicine.

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Can Zika Virus Damage an Infected Infant’s Brain After Birth?

           

Dr. Angela Rocha shows brain scans of a baby born with microcephaly at the Oswaldo Cruz Hospital in Recife, Brazil.  FELIPE DANA/AP

CLICK HERE - NEJM - Prolonged Shedding of Zika Virus Associated with Congenital Infection

CLICK HERE - Radiology - Congenital Brain Abnormalities and Zika Virus: What the Radiologist Can Expect to See Prenatally and Postnatally

statnews.com - by Helen Branswell - August 24, 2016

A new report from Brazil raises questions about whether the Zika virus can continue to damage an infected infant’s brain after birth.

An infant in Sao Paulo whose mother was infected late in her second trimester was born without any visible birth defects. But testing showed the baby had the Zika virus in his blood; the virus remained in his system for at least a couple of months.

At six months, it became apparent that the child had suffered Zika-related brain damage.

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Earthquake - Italy - 24 August 2016

                         

A strong Mw. 6.0 earthquake at a shallow depth of 4 km occurred at 01.36 UTC (03.36 local time) in Italy, in the province of Rieti (Lazio), at the border with Umbria and Abruzzi regions. The earthquake caused extensive damage in the area around the epicentre with a number of fatalities reported and a number of people under rubble or still missing as of 11.00 UTC (13.00 CET). Severe damage has been reported in the villages of Amatrice, Accumoli, Arquata del Tronto and Pescara del Tronto.

A list of information resources is provided below . . .

CLICK HERE - Humanity Road - Aug 2016 Italy Earthquake (Situation Reports and Information Resources)

CLICK HERE - GDACS - Earthquake Alert - Italy - 24 Aug 2016 01:36 UTC

CLICK HERE - USGS - Earthquake - M6.2 - 10km SE of Norcia, Italy

CLICK HERE - U.S. Embassy Rome, Italy - Emergency Message for U.S. Citizens: Italy Earthquake, August 24, 2016

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Study Shows Extent of Brain Damage From Zika Infections

           

Aedes aegypti mosquitoes are seen inside Oxitec laboratory in Campinas, Brazil, February 2, 2016.
REUTERS/Paulo Whitaker/File Photo

CLICK HERE - STUDY - Radiology - Congenital Brain Abnormalities and Zika Virus: What the Radiologist Can Expect to See Prenatally and Postnatally

reuters.com - Reporting by Julie Steenhuysen; Editing by Dan Grebler - August 23, 2016

A report released on Tuesday shows in graphic detail the kind of damage Zika infections can do to the developing brain - damage that goes well beyond the devastating birth defect known as microcephaly, in which the baby's head is smaller than normal.

The current Zika outbreak was first detected last year in Brazil, where the virus has been linked to more than 1,800 cases of microcephaly, which can cause severe developmental problems.

Prior research has shown the Zika virus attacks neural progenitor cells - a type of stem cell that develops into different types of nerve or brain cells.

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The Potential Zika Threat to Adult Brain Cells

           

Ueslei Marcelino / Reuters

CLICK HERE - RESEARCH - Zika Virus Infects Neural Progenitors in the Adult Mouse Brain and Alters Proliferation

New research has found evidence the mosquito-borne virus can adversely affect cells necessary for replenishing damaged neurons.

theatlantic.com - by Marina Koren - August 19, 2016

Zika is understood to pose the greatest threat to pregnant women and their fetuses, which can be born with severe brain defects if infected with the mosquito-borne virus. But new research suggests Zika may damage adult brains, too, giving scientists another thread to follow in their attempts to understand the virus as the number of infections continues to rise in South America, the Caribbean, and elsewhere.

U.S. researchers have found evidence that a certain kind of brain cell present in newborns that remains in some amounts in adulthood can be susceptible to Zika infection, according to a study published Thursday in the journal Cell Stem Cell.

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U.N. Admits Role in Cholera Epidemic in Haiti

           

Julener Buisserette sanitizes a tent with cholera patients in Port-Au-Prince, Haiti, in November 2010. (Nikki Kahn/The Washington Post)

nytimes.com - by Jonathan M. Katz - August 17, 2016

For the first time since a cholera epidemic believed to be imported by United Nations peacekeepers began killing thousands of Haitians nearly six years ago, the office of Secretary General Ban Ki-moon has acknowledged that the United Nations played a role in the initial outbreak and that a “significant new set of U.N. actions” will be needed to respond to the crisis.

The deputy spokesman for the secretary general, Farhan Haq, said in an email this week that “over the past year, the U.N. has become convinced that it needs to do much more regarding its own involvement in the initial outbreak and the suffering of those affected by cholera.” He added that a “new response will be presented publicly within the next two months, once it has been fully elaborated, agreed with the Haitian authorities and discussed with member states.”

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Zika Data From the Lab, and Right to the Web

A pregnant rhesus macaque monkey infected with the Zika virus. University researchers released a study that found the Zika virus persisted in the blood of pregnant monkeys for 30 to 70 days but only around seven days in others. Credit Scott Olson/Getty Images

Image:  A pregnant rhesus macaque monkey infected with the Zika virus. University researchers released a study that found the Zika virus persisted in the blood of pregnant monkeys for 30 to 70 days but only around seven days in others. Credit Scott Olson/Getty Images

nytimes.com - July 18th 2016 - Donald G. McNeil Jr.

Of the hundreds of monkeys in the University of Wisconsin’s primate center, a few — including rhesus macaque 827577 — are now famous, at least among scientists tracking the Zika virus.

Since February, a team led by David H. O’Connor, the chairman of the center’s global infectious diseases department, has been conducting a unique experiment in scientific transparency. The tactic may presage the evolution of new ways to respond to fast-moving epidemics.

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