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The mission of the Global Health Working Group is to explore and improve current and emerging states of health and human security worldwide.

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This Working Group is focused on exploring current and emerging states of health and human security worldwide.
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Aboubacar Conte admin Albert Gomez Allan Anthony Carrielaj
Chisina Kapungu ChrisAllen Corey Watts CPetry DeannaPolk Elhadj Drame
Gavin Macgregor... Hadiatou Balde hank_test jranck JSole Kathy Gilbeaux
Lisa Stelly Thomas loguest Maeryn Obley mdmcdonald MDMcDonald_me_com Mika Shimizu
mike kraft njchapman Norea Tiaji Salaam-Blyther tnovotny

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Nigeria Hit by Unprecedented Lassa Fever Outbreak

           

This year, the rats that carry Lassa fever may be more numerous, or more likely to harbor the virus.  Photo: Reuters/Stringer

CLICK HERE - reliefweb - Nigeria: Lassa Fever Outbreak

CLICK HERE - WHO - Nigeria - Lassa Fever

science.sciencemag.org - by Leslie Roberts - March 16, 2018

By early January, it was clear something “really, really extraordinary” was going on in Nigeria, says Lorenzo Pomarico of the Alliance for International Medical Action (ALIMA). Cases of Lassa fever, a rare viral hemorrhagic disease, were skyrocketing across the country—more were recorded in the first 2 months of 2018 than in any previous year. Unprepared for a disease that has no vaccines or drugs and kills 20% to 30% of those it sickens, eight health care workers were infected early on and three died. “Something was going very wrong with the outbreak,” Pomarico says.

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Beware 'Disease X': The Mystery Killer Keeping Scientists Awake at Night

CLICK HERE - WHO - R&D Blueprint - List of Blueprint priority diseases

telegraph.co.uk - by Alanna Shaikh - March 10, 2018

Over two days in early February, the World Health Organisation (WHO) convened an expert committee at its Geneva headquarters to consider the unthinkable.

The goal was to identify pathogens with the potential to spread and kill millions but for which there are currently no, or insufficient, countermeasures available . . . 

 . . . In addition to eight frightening but familiar diseases including Ebola, Zika, and Severe Acute Respiratory Syndrome (SARS), the list included a ninth global threat: Disease X.

(READ COMPLETE ARTICLE)

ALSO SEE RELATED ARTICLE HERE - Mysterious 'Disease X' Could Be The Next Deadly Global Epidemic, WHO Warns

 

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Stopping Pandemic X: DARPA Names Researchers Working to Halt Outbreaks

           

globalbiodefense.com - February 22, 2018

CLICK HERE - DARPA - Pandemic Prevention Platform (P3)

The Defense Advanced Research Projects Agency (DARPA) launched the Pandemic Prevention Platform (P3) program in 2017, with the eventual goal of halting the spread of any infectious disease outbreak before it can escalate into a pandemic . . . 

 . . . In contrast with state-of-the-art medical countermeasures, which typically take many months or even years to develop, produce, distribute, and administer, the envisioned P3 platform would cut response time to weeks and stay within the window of relevance for containing an outbreak.

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Chinese Scientists Find How Bats Carry Viruses Without Getting Sick

xinhuanet.com - Editor: Liu - February 23, 2018

CLICK HERE - Dampened STING-Dependent Interferon Activation in Bats

WASHINGTON, Feb. 22 (Xinhua) -- Chinese scientists have identified the secret of bats that harbor highly pathogenic viruses like Ebola, Marburg and SARS coronavirus but do not show clinical signs of disease.

In a paper published on Thursday in the journal Cell Host & Microbe, scientists at the Wuhan Institute of Virology in China find that in bats, an antiviral immune pathway called the STING-interferon pathway is dampened, so bats can maintain just enough defense against illness without triggering a heightened immune reaction.

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BRIEF: The Virome Project Aims to Prepare Before the Next Pandemic

           

Ebola virus budding from surface of cells, from a scanning electron micrograph.  Image credits: NIAID

CLICK HERE - The Global Virome Project

insidescience.org - by Benjamin Plackett - February 22, 2018

 . . . In an article published in Science magazine today, Daszak and a group of like-minded scientists described a new initiative, called the Virome project, that would identify and catalogue hundreds of thousands of yet-to-be-discovered viruses found in wild animals.

The team estimates that there are about 1.6 million undiscovered virus types and that somewhere between 631,000-827,000 could potentially spill over into humans. The viruses are found mostly in wild mammals.

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Ebola Had Significant Collateral Damage to Liberians' Health

           

A mural announces anti-Ebola sentiment outside a business in Harper, Liberia.  Brad Wagenaar

CLICK HERE - STUDY - The 2014–2015 Ebola virus disease outbreak and primary healthcare delivery in Liberia: Time-series analyses for 2010–2016

After the 2014 outbreak, the population's needs were often unmet in terms of primary care, mother-child health, and immmunizations.

newsroom.uw.edu - by Ashlie Chandler - February 20, 2018

The 2014 Ebola outbreak in West Africa rapidly became the deadliest occurrence of the disease — claiming 4,809 lives in Liberia alone.  Now new research from the University of Washington suggests Ebola's collateral effects on that nation's health system likely caused more deaths than Ebola did directly.

The study, published today in PLOS Medicine, found that it only took four months for Liberia to lose between 35 percent and 67 percent of primary health care services after the  Ebola outbreak began.

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Other Viruses Cause Zika-Like Damage to Fetuses, Study Finds

           

Zika's blood-sucking predator

CLICK HERE - STUDY - Zika virus–related neurotropic flaviviruses infect human placental explants and cause fetal demise in mice

cnn.com - by Susan Scutti - February 18, 2018

In 2016, the US Centers for Disease Control and Prevention confirmed that the Zika virus caused birth defects in babies born to women who had been infected while pregnant. This was the first mosquito-borne disease known to cause birth defects . . . 

 . . . Now, a study suggests that two viruses that are related to Zika can cause similar birth defects.

West Nile and Powassan viruses caused fetal death in infected pregnant mice, the researchers say.

(READ COMPLETE ARTICLE)

CLICK HERE - NEJM - Zika Virus and Birth Defects — Reviewing the Evidence for Causality

 

 

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China Confirms First Ever Human Case of H7N4 Bird Flu

           

China has confirmed first ever human case of H7N4 bird flu Photograph: Kin Cheung/AP

CLICK HERE - The Government of Hong Kong Special Administrative Region - Press Release

A 68-year-old patient from Jiangsu province, who has since recovered, developed symptoms on Christmas Day and was admitted to hospital

theguardian.com - by Tom Phillips - February 15, 2018

A woman from eastern China has been confirmed as the first ever human case of H7N4 bird flu, according to Chinese authorities . . .

 . . . The 68-year-old patient from Jiangsu province, who has since recovered, developed symptoms on 25 December, was admitted to hospital for treatment on 1 January and was released on 22 January. 

“She had contact with live poultry before the onset of symptoms,” Hong Kong’s centre for health protection (CHP) said in an alert on Wednesday evening. “According to a report from the Chinese centre for disease control and prevention, upon analysis, the genes of the virus were determined to be of avian origin.”

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Zika Linked to a Spike in Birth Defects in the U.S.

CLICK HERE - CDC - MMWR - Population-Based Surveillance of Birth Defects Potentially Related to Zika Virus Infection — 15 States and U.S. Territories, 2016

time.com - by Alexandra Sifferlin - January 25, 2018

Areas in the United States where Zika spread locally, like Florida and Texas, experienced a spike in birth defects.

According to a new report from the U.S. Centers for Disease Control and Prevention (CDC), areas in South Florida, parts of Texas and Puerto Rico saw a 21% increase in birth defects strongly linked with Zika in the last half of 2016, compared to the first part of the year.

(CLICK HERE - READ COMPLETE ARTICLE)

CLICK HERE - CDC - NEWSROOM RELEASE - More birth defects seen in parts of U.S. with local Zika spread

 

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Researchers Identify Three New Mosquito Vectors of Zika in Mexico

CLICK HERE - RESEARCH - Zika Virus in Salivary Glands of Five Different Species of Wild-Caught Mosquitoes from Mexico

mvcac.org - January 25, 2018

Researchers identified three new mosquito carriers of Zika virus in Mexico and say all three are potential vectors of the disease.

Writing in Scientific Reports, the researchers reported isolating Zika virus from the salivary glands of wild-caught female Culex coronator, C.tarsalis and Aedes vexans mosquitoes, as well as other previously reported vectors, including A. aegypti, the primary driver of the recent Zika virus epidemic in the Americas. They also isolated Zika from different body parts of wild-caught female C. quinquefasciatus mosquitoes and whole males from the A.aegypti and C. quinquefasciatus species.

“Our findings strongly suggest that all the species reported herein are potential vectors for [Zika virus],” they wrote.

(READ COMPLETE ARTICLE)

 

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