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The mission of the Global Health Working Group is to explore and improve current and emerging states of health and human security worldwide.

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This Working Group is focused on exploring current and emerging states of health and human security worldwide.
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Aboubacar Conte admin Albert Gomez Allan Anthony Carrielaj
Chisina Kapungu ChrisAllen Corey Watts CPetry DeannaPolk Elhadj Drame
Gavin Macgregor... Hadiatou Balde hank_test jranck JSole Kathy Gilbeaux
Lisa Stelly Thomas loguest Maeryn Obley mdmcdonald MDMcDonald_me_com Mika Shimizu
mike kraft njchapman Norea Tiaji Salaam-Blyther tnovotny

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Donors and Drug Makers Offer $500 Million to Control Global Epidemics

           

A child born with microcephaly caused by the Zika virus, during an evaluation at Fundação Altino Ventura in Recife, Brazil. A group of prominent donors announced Wednesday that they had raised almost $500 million for a new partnership to stop epidemics before they spiral out of control. Credit Adriana Zehbrauskas for The New York Times

nytimes.com - by DONALD G. McNEIL Jr. - January 18, 2017

Stung by the lack of vaccines to fight the West African Ebola epidemic, a group of prominent donors announced Wednesday that they had raised almost $500 million for a new partnership to stop epidemics before they spiral out of control.

The partnership, the Coalition for Epidemic Preparedness Innovations, will initially develop and stockpile vaccines against three known viral threats, and also push the development of technology to brew large amounts of vaccine quickly when new threats, like the Zika virus, arise.

With enough money and scientific progress, the strategy could bring a drastic change in the way the world tackles pandemics.

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DNA-Testing Smartphone Aims to Tackle Drugs Resistance

submitted by Alicia Juarrero

           

UCLA, STOCKHOLM UNIVERSITY AND UPPSALA UNIVERSITY

CLICK HERE - Nature Communications - Targeted DNA sequencing and in situ mutation analysis using mobile phone microscopy

bbc.com - by Leo Kelion - January 18, 2017

Scientists have built a DNA-analysing smartphone attachment that is a fraction of the cost of lab-based kit.

The creators of the phone-powered pathology microscope believe it could be mass produced for less than $500 (£406) a unit.

They say it could help doctors treat cancer, tuberculosis and other diseases more effectively than is sometimes possible in the developing world.

But a UK firm says it is developing a more advanced and cheaper alternative.

Details of the peer-reviewed project are published in the journal Nature Communications.

(READ COMPLETE ARTICLE)

 

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A Woman Was Killed by a Superbug Resistant to All 26 American Antibiotics

           

The Klebsiella pneumoniae organism in a petri dish.  GARY CAMERON / REUTERS

CLICK HERE - STUDY - CDC - MMWR - Notes from the Field: Pan-Resistant New Delhi Metallo-Beta-Lactamase-Producing Klebsiella pneumoniae — Washoe County, Nevada, 2016

No Antibiotic In The U.S. Could Save This Woman. We Should All Be Worried.

This is one of the first cases of a pan-resistant infection in America.

huffingtonpost.com - by Anna Almendraia - January 13, 2017

The recent death of a woman in Reno, Nevada, from an infection resistant to every available kind of antibiotic in the U.S. highlights how serious the threat of antibiotic-resistant superbugs has become. 

Experts say that while cases of a bacteria resistant to all antibiotics are still extremely rare in the U.S., we should expect to see more in the future. 

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First Ebola-Related Death from Breast Milk Transmission Reported in Guinea

Sissoko D, et al. Clin Infect Dis. 2016;doi:10.1093/cid/ciw79.

CLICK HERE - STUDY -  Ebola virus persistence in breast milk after no reported illness: a likely source of virus transmission from mother to child

healio.com - January 10, 2017

Genomic analysis confirmed that the 2015 death of a 9-month-old Guinean infant from Ebola virus was the result of transmission through the breast milk of her asymptomatic mother, according to a recent case study.

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Ebola RNA Found Hiding in Healthcare Worker’s Lungs

           

WIKIMEDIA, HELLERHOFF

CLICK HERE - STUDY - Detection of Viral RNA in Tissues following Plasma Clearance from an Ebola Virus Infected Patient

A case study reports evidence of viral replication lingering in the respiratory tract of an infected person, even after their blood was Ebola free.

the-scientist.com - by Bob Grant - January 5, 2017

Ebola virus may linger and continue to replicate in the lungs of patients recovering from infection, even after viral RNA is no longer detectable in their bloodstreams, according to a case study published today (January 5) in PLOS Pathogens. . . .

 . . . Ippolito and his colleagues monitored the Ebola-infected patient, who was moved from West Africa to a hospital in Italy in 2015, over the course of their infection. They found viral RNA and other markers of viral replication in the patient’s lungs five days after such markers were no longer detectable in the blood.

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Haiti Receives 82 Tons of Urgently Needed Medical Aid

           

Direct Relief staff stage hundreds of pallets bound for Haiti in the organization’s Santa Barbara warehouse on Dec. 20, 2016. The shipment, valued at $39.9 million, is the largest in the organization’s 69-year history.

directrelief.org

SANTA BARBARA, Calif., Dec. 28, 2016 – Direct Relief today airlifted 82 tons of medical aid to Haiti to help treat cholera and other diseases that have spread widely since Hurricane Matthew struck in October, incapacitating the country’s already overstretched health care system.

Direct Relief’s warehouse staff worked through the holidays to prepare 258 pallets of essential medications and supplies with a wholesale value of $39.9 million. The shipment – the largest by value in Direct Relief’s 69-year history – traveled by a chartered cargo jet from Los Angeles to Port-au-Prince.

Dozens of health care companies that support Direct Relief’s humanitarian health efforts contributed the supplies, augmented by funds contributed by donors to Direct Relief specifically for Hurricane Matthew assistance.

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El Niño and Global Warming Blamed for Zika Spread

           

A female Aedes albopictus mosquito feeding on a human host. Credit: James Gathany CDC

CLICK HERE - STUDY - PNAS - Global risk model for vector-borne transmission of Zika virus reveals the role of El Niño 2015

scientificamerican.com - by Kavya Balaraman - December 21, 2016

Mosquito-borne diseases like Zika can be extremely sensitive to climatic changes

The combination of climate change and last year’s El Niño phenomenon likely created the perfect playground for the Zika virus to spread rapidly across South America, a new study finds.

Both the Zika virus and the mosquitoes that carry it have been present in different parts of the world for a while. But several factors, including specific climatic conditions, could have catapulted the disease to public health emergency status, according to researchers from the University of Liverpool.

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Final Trial Results Confirm Ebola Vaccine Provides High Protection Against Disease

                                               

who.int

23 DECEMBER 2016 | GENEVA - An experimental Ebola vaccine was highly protective against the deadly virus in a major trial in Guinea, according to results published today in The Lancet. The vaccine is the first to prevent infection from one of the most lethal known pathogens, and the findings add weight to early trial results published last year.

The vaccine, called rVSV-ZEBOV, was studied in a trial involving 11 841 people in Guinea during 2015. Among the 5837 people who received the vaccine, no Ebola cases were recorded 10 days or more after vaccination. In comparison, there were 23 cases 10 days or more after vaccination among those who did not receive the vaccine.

The trial was led by WHO, together with Guinea’s Ministry of Health and other international partners.

(READ COMPLETE ARTICLE)

CLICK HERE - The Lancet - Efficacy and effectiveness of an rVSV-vectored vaccine in preventing Ebola virus disease: final results from the Guinea ring vaccination, open-label, cluster-randomised trial (Ebola Ça Suffit!)

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Birth Defects Among Fetuses and Infants of US Women With Evidence of Possible Zika Virus Infection During Pregnancy

jamanetwork.com - December 13, 2016 - doi:10.1001/jama.2016.19006

In this report based on preliminary data for pregnant women in the USZPR with laboratory evidence of possible Zika virus infection, 6% overall had a fetus or infant with evidence of a Zika-related birth defect, and among women with timing of possible Zika infection exclusively during the first trimester, 11% had a fetus or infant with a birth defect. The birth defects primarily involved included microcephaly with brain abnormalities, such as intracranial calcifications. Preliminary estimates from the USZPR were within the range of 1% to 13% risk of microcephaly following first-trimester maternal Zika virus infection modeled on the outbreak in Bahia, Brazil, lending support to the credibility of these estimates.

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Negative Effects Of Zika During Pregnancy More Common Than Realized

           

Juan Pedro, who has microcephaly and turned one-year-old on December 4, sits in a specially designed chair to keep him upright as he is kissed by his sister Jennifer Karine on December 12, 2016 in Recife, Brazil. As many of the babies with microcephaly, believed to be linked to the Zika virus, turn one-year-old in Recife, doctors and mothers are adapting and learning treatments to assist and calm the children. Many of the children are suffering a plethora of difficulties including vision and hearing problems with doctors now labeling the overall condition as 'Congenital Zika Syndrome'. (Photo by Mario Tama/Getty Images)

CLICK HERE - STUDY - NEJM - Zika Virus Infection in Pregnant Women in Rio de Janeiro

forbes.com - by Tara Haelle - December 14, 2016

The rate of birth defects, disability and brain irregularities in babies exposed to the Zika virus is considerably higher than was previously believed — regardless of the mother’s symptoms or the trimester she had the infection — found a new study . . .

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