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The mission of the Global Health Working Group is to explore and improve current and emerging states of health and human security worldwide.

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This Working Group is focused on exploring current and emerging states of health and human security worldwide.
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Chisina Kapungu ChrisAllen Corey Watts CPetry DeannaPolk Elhadj Drame
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Ebola’s Newest Casualty: Health Care

      

Baz Ratner/Reuters

thedailybeast.com - by Sheldon Yett - April 3, 2015

The worst of the Ebola epidemic may be over in Liberia, but the damage it inflicted on an already weak health care system could have catastrophic consequences.

Here in Liberia, the goal of zero Ebola cases is tantalizingly close. Only one new case has been recorded since 19 February, and 13 of the country’s 15 counties have not reported any new cases for over 42 days. But Ebola’s impact will be felt long after the last case has been treated.      

As the battle against Ebola continues, the threat of outbreaks of measles, whooping cough and other vaccine-preventable diseases remains high. Given the mobility of Liberia’s population, the danger is that these diseases could spread with the same devastating rapidity that Ebola did.

Malnutrition rates have also increased, and a large proportion of the population is still not using health facilities for fear of contracting Ebola.

(READ COMPLETE ARTICLE)

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Ebola Upsurge Could Undo Progress in Blink of an Eye, Warns Expert

‘Flare-ups occur and, frankly, before you can blink, we could be back to a situation where Ebola starts climbing up again,’ says the UN special envoy for Ebola, David Nabarro. Photograph: Salvatore Di Nolfi/EPA

UN special envoy for Ebola sounds cautionary note amid fears that individuals who ignore official advice could cause spike in infection rate

theguardian.com - by Sam Jones - March 26, 2015

Despite the massive push to bring the number of new Ebola cases down to zero as quickly as possible, there will inevitably be “flare-ups” that could reverse the overall downward trend and prove difficult to contain, the UN’s response co-ordinator has warned.

Dr David Nabarro, the UN’s special envoy for Ebola, said the huge medical, administrative and logistical operation to fight the disease could still be set back by individuals ignoring official advice. . . .

. . . “It’s [about] getting the full geographical coverage and linking everyone together with the most excellent data systems so the databases are comparable and we don’t end up with a mess because different people can’t talk to each other,” he explained.

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WHO - Ebola Situation Report - 1 April 2015

                                       

who.int - April 1, 2015

SUMMARY

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Sierra Leone to start laying off Ebola workers as cases fall: president

REUTERS  by Umaru Fofana                                                                             April l, 2015

FREETOWN-- Sierra Leone's President Ernest Bai Koroma said on Wednesday authorities would soon start laying off staff recruited to fight Ebola as the numbers of cases decline, but these workers would be employed elsewhere, where possible....

Addressing the country about the outbreak, Koroma said the infection rate was falling "week by week" and the number of treatment facilities and staff would be reduced, despite the need for continued vigilance....

At the peak of the crisis last year, authorities were struggling to recruit local and foreign medics to tackle Ebola, which has killed nearly 500 local health workers in West Africa, according to United Nations statistics.

Read complete storyy.
http://www.reuters.com/article/2015/04/02/us-health-ebola-leone-idUSKBN0MT01120150402

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Liberia, Sierra Leone gain in Ebola crisis; Guinea struggles

ASSOCIATED PRESS  by Sarah DiLorenzo                                                               April 2, 2015      

(Scroll below for related Wall Street Journal story.)   

DAKAR, Senegal (AP) — When will the world's largest and longest Ebola outbreak end? The West African countries of Sierra Leone and Liberia both appear to be on steady paths to ending the epidemic. The wild card is Guinea, where Ebola hasn't burned as hot but remains stubbornly entrenched.

 

In this file photo dated Friday, March. 27, 2015, a usually busy street is deserted as Sierra Leone enters a three day country wide lockdown on movement of people due to the Ebola virus in the city of Freetown, Sierra Leone. Sierra Leone's 6 million people were told to stay home for three days, except for religious services, beginning Friday as the West African nation attempted a final push to rid itself of Ebola. (AP Photo/ Michael Duff, FILE)

Liberia's last Ebola patient died March 27; it is now counting down the 42 days it must wait to be declared free of Ebola. Meanwhile, Sierra Leone recorded no new infections Wednesday for the second time; on average, it has logged a handful each day in recent days.

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Merck, NewLink Ebola vaccine appears safe, effective in new studies

REUTERS by Sharon Bagley                                                                      April 1, 2015

Early-stage trials of an experimental Ebola vaccine, two in the United States and four in Africa and Europe, have found that it appears to be safe and triggered robust production of Ebola-fighting antibodies, scientists reported on Wednesday.

Since trials cannot ethically expose volunteers to Ebola, the production of antibodies is a proxy for whether vaccines could prevent or even treat the disease.

The trials all tested a vaccine called VSV-ZEBOV, which was developed at the Public Health Agency of Canada and licensed to NewLink Genetics Corp and then to Merck & Co Inc. It consists of a cattle virus called rVSV that has been engineered to carry Ebola genes, which produce proteins meant to trigger production of anti-Ebola antibodies.

According to separate teams of scientists, that is what happened, two papers in the New England Journal of Medicine reported.

Read complete story.
http://www.reuters.com/article/2015/04/01/us-health-ebola-vaccine-idUSKBN0MS5DN20150401

Read NEW ENGLAND JOURNAL OF MEDICINE  papers

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App enables self-reporting of possible Ebola symptoms in Maryland

ASSOCIATED PRESS                                                                                     April 1, 2015

BALTIMORE — A Baltimore company and Maryland public health officials are announcing a smartphone and Web application for self-reporting possible Ebola symptoms.

Emocha Mobile Health Inc. said Wednesday that people returning from affected West African nations can use the app to report their temperature and any symptoms twice daily to the Department of Health and Mental Hygiene. The federal government recommends such reporting for 21 days.

The state health agency has operated a call center since October for monitoring people known to have been in affected countries. The app eventually will link to the state's database of such individuals to automate the reporting of data to Maryland and federal authorities.

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Ebola diaries: Regaining the people’s trust

WHO                                                                                                          March 31, 2015
Cristiana Salvi, a risk communications specialist from WHO’s European regional office was deployed to Guinea at the end of April – early May 2014 to provide social mobilization support to the Ebola response. Social mobilization involves working with communities to gain their acceptance of the need for early identification of people with illness, early treatment and identification and follow up of all people who have been in contact with people confirmed to have Ebola virus disease.

 Cristiana was among the first from WHO offices other than Headquarters and the African office to provide support to the field response, many others followed from the “wider WHO”. She travelled to Gueckedou where communities had begun to hide people who were sick, fearing treatment centres, believing rumours Ebola response teams were there for sinister purposes. This is what she found.

Excerpt:

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BioCryst gets HHS contract for Ebola drug development

CENTER FOR INFECTIOUS DISEASE RESEARCH AND POLICY by Lisa Schnerring               March 31, 2015

The US Department of Health and Human Services (HHS) announced today that it has awarded BioCryst Pharmaceuticals a $12 million grant to continue development of BCX4430, a small-molecule drug designed to treat Ebola and other filovirus infections, and to prepare for large-scale manufacturing of the agent.

Studies in nonhuman primates suggest that the drug is effective against Ebola and Marburg viruses and could be useful as a broad-spectrum antiviral, the HHS said in a statement. BCX4430 is currently in phase 1 human trials, and if results show safety, it could be one of the treatments to be tested for efficacy in clinical trials.

BCX4430 is the first small-molecule Ebola treatment that BARDA has supported. Other Ebola products in development that have received BARDA funding include the monoclonal antibody cocktail ZMapp and three vaccines.
Read complete story.
http://www.cidrap.umn.edu/news-perspective/2015/03/biocryst-gets-hhs-contract-ebola-drug-development

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Faulty modeling studies led to overstated predictions of Ebola outbreak

MEDICAL EXPRESS                                                                       MARCH 31, 2015

(scroll down for complete paper.)

Frequently used approaches to understanding and forecasting emerging epidemics—including the West African Ebola outbreak—can lead to big errors that mask their own presence, according to a University of Michigan ecologist and his colleagues.

Last September, the U.S. Centers for Disease Control and Prevention estimated—based on computer modeling—that Liberia and Sierra Leone could see up to 1.4 million Ebola cases by January 2015 if the viral disease kept spreading without effective methods to contain it. Belatedly, the international community stepped up efforts to control the outbreak, and the explosive growth slowed.

"Those predictions proved to be wrong, and it was not only because of the successful intervention in West Africa," King said. "It's also because the methods people were using to make the forecasts were inappropriate."

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