The contribution of Ebola viral load at admission and other patient characteristics to mortality in a Médecins Sans Frontières (MSF) Ebola Case Management Centre (CMC), Kailahun, Sierra Leone, June –October, 2014

m.jid.oxfordjournals.org - J Infect Dis. (2015) doi: 10.1093/infdis/jiv304 First published online: May 22, 2015

Abstract

This paper describes patient characteristics, including Ebola viral load, associated with mortality in an MSF Ebola case management centre.

Out of 780 admissions between June and October 2014, 525 (67%) were positive for Ebola with a known outcome. The crude mortality rate was 51% (270/525). Ebola viral load (whole blood sample) data was available on 76% (397/525) of patients. Univariate analysis indicated viral load at admission, age, symptom duration prior to admission and distance travelled to the CMC were associated with mortality (p value<0.05). The multivariable model predicted mortality in those with a viral load at admission greater than 10 million copies per millilitre (p value<0.05, Odds Ratio>10), aged 50 years or more (p value=0.08, Odds Ratio=2) and symptom duration prior to admission less than 5 days (p value=0.14). The presence of confusion, diarrhoea and conjunctivitis were significantly higher (p value<0.05) in Ebola patients who died.

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Malaysian quake toll hits 13 dead, 6 missing

Kundasang (Malaysia) (AFP) - A strong earthquake that jolted Mount Kinabalu in Malaysia has left 13 people dead and another six missing on Southeast Asia's highest peak, an official said Saturday.

 The 6.0-magnitude quake struck early Friday near the picturesque mountain, a popular tourist destination, sending landslides and huge granite boulders tumbling down from its wide, 4,095-metre-high (13,435-foot) crown.

"There are 13 (dead) bodies. Two yesterday and 11 today. We've got six people still missing. I cannot confirm with you where they are from," Mohammad Farhan Lee Abdullah, police chief of the town of Ranau near the mountain, told AFP.

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http://news.yahoo.com/11-dead-8-missing-malaysian-peak-quake-050758059.html

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Guinea extends Ebola emergency measures

AFP     JUNE 6, 2015

CONAKRY--Ebola-hit Guinea has extended a health emergency declared in March until the end of June, citing the persistence of the deadly virus in the country, the presidency said on Saturday.


Workers walk at the Donka Ebola treatment center on May 2, 2015 in Conakry (AFP Photo/Cellou Binani)

The decision was taken on Friday by President Alpha Conde, the statement said, after he met his counterpart from Sierra Leone, Ernest Bai Koroma.

In August last year, Conde declared a health emergency for the whole of Guinea. Then on March 28, 2015, he decreed a "reinforced health emergency" for five provinces in the west and southwest of the West African country.

"Given the persistence of the epidemic... in parts of Guinea and Sierra Leone," Conde and Koroma decided "to extend the reinforced emergency measures in their countries until June 30, 2015", the Guinean presidency said.

Read complete story.
http://news.yahoo.com/guinea-extends-ebola-emergency-measures-201127353.html

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West Africa Struggles to Rebuild Its Ravaged Health-Care System

WALL STREET JOURNAL by Betsy McKay  June 4, 2015
HARPER, Liberia --The deadly disease may have receded, but it is still exacting a heavy toll. Run-down, poorly staffed and equipped health facilities allowed Ebola to explode.

 Since it was identified in early 2014, the epidemic has claimed the lives of 507 health-care workers in three West African countries, all of which already were short of medical professionals. The health-care system was so overwhelmed with Ebola victims that many other patients couldn’t receive care for malaria, heart disease or pregnancy complications. That bill is coming due.

“There are more people who are going to die from Ebola, but not have Ebola,” says Paul Farmer, a Harvard professor and co-founder of the Boston-based charity Partners in Health.

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Rethinking the Global Health Architecture

chathamhouse.org

The Centre on Global Health Security is engaging leading thinkers in a process of dialogue, research and analysis on the future of the global health system.

During the past 20 years there has been major progress in public health across the world. Life expectancy has increased and many more people live healthy lives. However, major needs remain, and in many places inequalities in economic status and health have increased. Given that both the development challenges and the economic situation are changing across the world, the global system needs to adapt.

Based on where we are today and future needs, the key questions are:

    Is the system fit for purpose?
    Are the purposes of the different parts of the system clearly defined?
    What is the role of the UN system within an international system that has changed and continues to change?

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Strengthening Data Sharing for Public Health

chathamhouse.org

This project aims to develop guidelines on how to create the right environment for public health data sharing and achieve good practice. The project will take these recommendations to key stakeholders within global health to provide support for pushing the established norms for data sharing towards a model where data are shared as openly as is possible and appropriate.

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Ebola Response Reveals the Need for New Models for Collaboration Between the Private and Public Sectors

A Report by the World Economic Forum and BCG Analyzes the Private Sector's Response to the Ebola Outbreak and Distills Lessons for Public-Private Partnerships in Future Health Crises

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BOSTON CONSULTING GROUP -MARKETWIRED June 4, 2014

CAPE TOWN, SOUTH AFRICA-- The private sector played an important role in the global response to the Ebola outbreak in West Africa not only by providing financial and in-kind donations but also by acting as a partner to support response activities.

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Global health leaders ask G7 for post-Ebola rapid response unit

(Two stories. Scroll down.)
REUTERS by Kate Kelland                                                           June 5, 2015
LONDON -- Global health leaders will ask G7 leaders this weekend to back the creation of a specialist rapid response unit to tackle outbreaks of infectious killer diseases.

The corpse of a patient who passed away is given back to the family for funerals after being decontaminated by the MSF teams. It was washed with chlorine solution and put it in a hermetic bag also disinfected to leave the high risk area.

The move reflects how the World Health Organization in particular was caught unprepared last year by Ebola, which spread through three West African countries, has killed 11,000 people, and will not be stamped out before the end of this year.

Jeremy Farrar, director of the Wellcome Trust global health charity, said the unit should come under the WHO, but be free of bureaucracy and able to act independently "in days" when a potentially fatal epidemic begins...

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Rebuilding Nepal to Survive the Next Quake

      

Minister for Industry has handed 60 temporary shelters to sixty families affected by the recent earthquake at Ananta Lingeshwor VDC of Bhaktapur.

newsweek.com - by Thakur Amgai - May 26, 2015

The powerful earthquake that hit Nepal on April 25 razed Anantaling, a small, ancient hill settlement 15 miles southeast of the capital, Kathmandu. Each of the 60-odd houses in Anantaling collapsed into rubble, and throughout the Bhaktapur district, 120,000 people were displaced. . . .

. . . Manabiya Astha Nepal, a nongovernmental organization (NGO) constructs temporary shelters for villagers by arching corrugated tin sheets into tunnel-like structures. . . .

. . . The design has a long history of success. . . .

. . . The cost for one of these shelters is only about $100, and the whole thing takes just two or three hours for two people to build. In addition, the materials are reusable. . . .

. . . "It is the only way to meet the needs of the masses before the monsoon arrives."

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Science Publishes New NOAA Analysis: Data Show No Recent Slowdown in Global Warming

A new NOAA study published online today in the journal Science finds that the rate of #globalwarming during the last 15...

Posted by National Oceanic and Atmospheric Administration (NOAA) on Thursday, June 4, 2015
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Ebola activity heats up as West Africa's rainy season begins

CIDRAP NEWS by Lisa Schnirring                                                                               June 3, 2015

(Scroll down for WHO stuation report.)

In  its weekly epidemiologicpidemiologic profile of the outbreak Wednesday, the World Health Organization (WHO) said Ebola activity in Guinea and Sierra Leone has become more intense and widespread since May 10, when the region saw cases hit a 10-month low.

Last week the two countries reported 25 new lab-confirmed cases, 13 in Guinea and 12 in Sierra Leone. The number is up from 12 reported the week before.

Overall, the total of confirmed, probable, and suspected cases in the two countries and Liberia—which is now Ebola free—has risen to 27,145, including 11,147 deaths, the WHO said.

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Don't Fall Behind as More Climate Legislation Rules the World

           

London School of Economics

greenbiz.com - by Michael Mathres - June 4, 2015

CLICK HERE - REPORT - 2015 Global Climate legislation Study

A lot of times businesses look to or blame,  governments for a lack of a national strategic economical direction for tackling climate change. This often leads to climate inertia where each party looks to the other for leadership and action.

However, according to a new report from the London School of Economics, this is no longer the case, and business have plenty of climate laws and policies from which to be inspired or adapt.

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After Ebola, world still unprepared for global pandemic: MSF

REUTERS by Maria Caspani                                                                                                June 4, 2015                     

NEW YORK -- The global health system is unable to handle another mass epidemic like the Ebola outbreak in West Africa, Médecins Sans Frontières said, urging wealthy nations to develop coordinated response plans and drugs to fight neglected diseases.

Late and slow international response, the absence of solid leadership as well as the lack of treatments and vaccines are a recurrent scenario in many of today's health emergencies and are not unique to the Ebola epidemic, the medical charity said.

"If a global pandemic were to strike tomorrow, there is still no well-resourced, coordinated international response in place to kick in," Joanne Liu, the international president of Médecins Sans Frontières (MSF), said in a statement on Wednesday.

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http://www.reuters.com/article/2015/06/04/us-global-health-ebola-idUSKBN0OK0MS20150604

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MERS Is Going to Spread in South Korea, the WHO Says

      

There are now 30 confirmed MERS cases in the country

time.com - by Helen Regan - June 3, 2015

The World Health Organization (WHO) said Tuesday that South Korea could expect further cases of the Middle East Respiratory Syndrome, or MERS, USA Today reports.

The disease has killed two people since the first case was confirmed on May 20.

According to Reuters, South Korea’s health ministry confirmed five new cases of the virus Wednesday, bringing the total number of cases in the country to 30—the largest outbreak outside of Saudi Arabia.

(READ COMPLETE ARTICLE)

ALSO SEE RELATED ARTICLES IN THE LINKS BELOW:

WHO - Middle East respiratory syndrome coronavirus (MERS-CoV) in the Republic of Korea
http://www.who.int/mediacentre/news/situation-assessments/2-june-2015-south-korea/en/

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Zoloft Could Be a Treatment for Ebola Virus

Researchers have identified two FDA-approved drugs that may be effective against the Ebola virus. This could shorten the time for developing new treatments.

HEALTHLINE NEWS  by  Shawn Radcliffe                                                         June 3, 2015

With a fast-moving epidemic like Ebola, doctors need to make use of every tool at their disposal. This includes giving a second life to already-approved drugs....

One research team is hoping to ease the epidemic by shortening the lengthy drug development process.

Their approach? Sifting through hundreds of existing drugs and other compounds for ones that might work against the Ebola virus....

Additional screening narrowed the list down to two potential drug candidates: Bepridil, a calcium channel blocker used to treat heart disease, and sertraline, an antidepressant more commonly known as Zoloft.

Both drugs are already approved by the FDA, although not for use against the Ebola virus.

Read complete story.

http://www.healthline.com/health-news/zoloft-could-be-a-treatment-for-ebola-virus-060315#1

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