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Experimental Ebola drug shelved; study explores virus clearance

CENTER FOR INFECTIOUS DISEASE POLICY AND RESEARCH by Lisa Schnirring     July 20, 2015

Tekmira Pharmaceuticals  announced that it has suspended development of TKM-Ebola, a drug cocktail that showed disappointing human trial results in West Africa, as a convalescent plasma trial at a Doctors Without Borders (MSF) facility in Guinea proceeded with no ill effects in patients so far...

In suspending TKM-Ebola development, the company said that a joint reevaluation of its contract with the US Department of Defense is under way.

In another development, MSF said a convalescent serum trial at its facility in Nongo, Guinea, has enrolled 101 people over the last few months, with no ill effects reported so far, according to a Jul 17 update on the outbreak. Patients at the Nongo treatment unit have the option to receive plasma donated by Ebola survivors....

Meanwhile, detailed testing at a Swiss hospital on a 43-year-old doctor infected with Ebola in Sierra Leone found that viral decay occurred in two phases, once starting 72 hours after symptom onset before any antiviral interventions, with acceleration in viral load decay after ZMAb infusion and oral favipiravir treatments began..

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Ebola crisis update MSF

 

MSF                                                  July 17, 2015

Though Ebola has faded from the news headlines, the epidemic in West Africa continues to claim lives today. Around 30 people become infected each week in Sierra Leone and Guinea – a number that would be considered a major disaster under normal circumstances – and the outbreak has recently re-emerged in Liberia.

  • Liberia: After being declared Ebola-free on 9May, six (6) new cases have been confirmed since the re-emergence of the virus at the end of June.
  • Guinea: 13 confirmed cases in the country in the week to 12July in three main hotspots (Forecariah, Boké/Fria, Conakry)
  • Sierra Leone: 14 confirmed cases in the country in the week to 12July in three main hotspots (Freetown, Port Loko, Kambia).  

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http://www.msf.org/article/ebola-crisis-update-17-july-2015

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Africa's Ebola outbreak has not run its course: U.N. envoy

REUTERS by Wendell Roelf   July 13, 2015
CAPE TOWN  - Africa's Ebola epidemic has not run its course and around 30 people are still getting infected each week, the United Nations' special envoy for the disease said on Monday.

The worst recorded outbreak of the virus has killed more than 11,000 people across West Africa since late 2013, but had abated in recent months. A new flare-up in Liberia is seen as a setback in the fight against it.

"The battle can be won, but it requires sustained effort, very careful negotiation with communities and perfection in follow-up of everybody who has been a contact,” David Nabarro told a media briefing in Cape Town...

"Probably about one third of these people are not coming from the contact list, which means they are surprise cases, and that’s a big worry," Nabarro earlier told a conference organised by the World Health Organization.
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http://news.yahoo.com/africas-ebola-outbreak-not-yet-run-course-u-082857000.html

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RECORDED VIDEO - Ebola Innovation for Impact 2015 - Game Change in Global Health Crisis Management

Side Event in Support of the UN Secretary-General’s International Ebola Recovery Conference July 9-10 2015

United Nations Headquarters - Conference Room 3, 13.15-14.30 pm (1:15pm-2:30pm, ET), 10 July 2015

As a side-event in support of the United Nations Secretary-General’s International Ebola Recovery Conference, Ebola Innovation for Impact 2015: Game Change in Global Health Crisis Management will bring together thought leaders in global health and technology to stimulate creative, collaborative and catalytic action, and to address the Ebola crisis with innovative solutions in the key, inter-linked areas of: Community Engagement and Mobilization; Private Sector Contribution and Collaboration; Data Systems Strengthening and Coordination; and, Emergency Infrastructure and Logistics.

Speakers include:

Dr. Barbara Bentein, UNICEF

Dr. Arnaud Bernaert, World Economic Forum (WEF)

Dr. Vinton G. Cerf, Google

Dr. Denis Gilhooly, Global Digital Health Initiative (GDHI)

Dr. Michael D. McDonald, Global Health Response & Resilience Alliance (GHRRA)

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International Ebola Recovery Conference, 9-10 July 2015

                                                            

ebolaresponse.un.org/recovery-conference

The road towards recovery

Guinea, Liberia and Sierra Leone have undertaken a remarkable effort to defeat the devastating Ebola outbreak. Thanks to those efforts and the support of the international community, the affected countries have seen a significant decline in the number of new cases. Recovery must now be pursued as part of the goal of “getting to zero and staying at zero,” as the response changes from emergency operations to multi-faceted, long-term support.

To this end, UN Secretary-General Ban Ki-moon is hosting an International Ebola Recovery Conference in New York to ensure that recovery efforts go beyond redressing direct development losses to build back better and ensure greater resilience.

The Conference will be held in cooperation with the Governments of Guinea, Liberia and Sierra Leone, and in partnership with the African Union, the African Development Bank, the European Union and the World Bank.

Aims of the Conference

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Ebola Innovation for Impact - 2015 Data Strengthening, Situational Awareness & Coordination Working Group Sessions

                                                                

1:00-5:00 pm, July 8, 2015

Manhattan Room, One UN Plaza, Second Floor

44th St. and 1st Ave., New York City

Agenda

On Wednesday July 8, 2015, an afternoon session will address Ebola response & recovery data strengthening, situational awareness, and coordination.  This working session will be held at U.N. headquarters in New York or a facility nearby from 1:00 PM to 5:00 PM.

Following are the proposed elements of the July 8 afternoon session:

1:00 PM           40 mins                        Opening Plenary Session

            An Overview of West Africa’s Current & Emerging Infrastructures

                        Barbara Bentein           UNICEF

                        Juliet Benford               Anthrologica

                        Sara Glass                   USAID, Global Development Lab

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Guinea's president on global aid push: 'Ebola forced us to change completely'

After the international community pledged $3.4bn for West Africa, Alpha Condé is cautiously optimistic and taking stock of lessons learned

Guinean president Alpha Conde speaks to UN members during an International Ebola Recovery Conference on 10 July. Photograph: EDUARDO MUNOZ ALVAREZ/AFP/Getty Images

THE GUARDIAN by Raya Jababi                        June 11, 2015
NEW YORK--More than a year after the charity Médecins Sans Frontières sounded the alarm on the Ebolaepidemic that would claim more than 11,000 lives, the international community on Friday pledged $3.4bn to help affected West African countries recover.

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Disproportionate Deaths Among Health Care Workers from Ebola Could Lead to Sharp Rise in Maternal Mortality Last Seen 20 Years Ago

                                                        

worldbank.org - Press Release

WASHINGTON DC, July 8, 2015—The loss of health workers due to the Ebola epidemic in West Africa may result in an additional 4,022 deaths of women each year across Guinea, Liberia and Sierra Leone as a result of complications in pregnancy and childbirth. 

According to the new World Bank report Healthcare Worker Mortality and the Legacy of the Ebola Epidemic published in The Lancet Global Health today, the recent outbreak of Ebola in West Africa could leave a legacy significantly beyond the deaths and disability caused directly by the disease itself.

The loss of health workers to Ebola could increase maternal deaths up to rates last seen in these countries 15-20 years ago,” says Markus Goldstein, Lead Economist at the World Bank Group and a co-author of the report who heads the World Bank’s Africa Gender Innovation Lab.

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International Community Pledges More Than $5 Billion Dollars to Help Recovery of Ebola-Affected Countries

                                         

un.org - July 10, 2015

The international community has pledged more than five billion dollars to support Guinea, Liberia and Sierra Leone in their efforts to recover from the devastating effects of Ebola, at a high level United Nations Conference in New York today (Friday).

Opening the International Ebola Recovery Conference United Nations Secretary-General Ban Ki-moon said: “Together, let us jumpstart a robust recovery process over the next two years, and usher in a better future for generations to come.”

The Secretary-General was joined by the Presidents of Guinea, Liberia and Sierra Leone, and the Secretary-General of the Mano River Union, who were seeking international support as well as financial commitments for their national and regional recovery strategies over the next two years.

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Lack of People, Supplies and Money Plague Africa's Ebola Fight - Experts

      

Health workers put on protective gear before entering a quarantine zone at a Red Cross facility in the town of Koidu, Kono district in Eastern Sierra Leone December 19, 2014.  Reuters/Baz Ratner

reuters.com - by Leslie Gevirtz - July 8, 2015

NEW YORK (Thomson Reuters Foundation) - Three Ebola-stricken countries will seek nearly $700 million in aid at a U.N. conference this week to rebuild their devastated health care systems, the World Health Organization said.

Guinea, Liberia and Sierra Leone, which are all experiencing a resurgence of the deadly hemorrhagic fever, have budgeted a little more than $2 billion between them to restore their health systems.

But, according to WHO, to reach that goal they will still need $696 million in aid from donor nations.

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