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A Chemical Within a Traditional Chinese Medicine Has been Found to Be Effective Against Ebola

      

Health workers in protective clothing speak with new arrivals in the outpatient waiting room of Redemption Hospital, formerly an Ebola holding centre, in Liberia.  John Moore/Getty Images

CLICK HERE - SCIENCE - REPORT - Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment

businessinsider.com.au - by Chris Pash - February 27, 2015

A chemical found in the Chinese herb known as Han Fang ji switches off the channels which the Ebola virus uses to enter and infect cells, according to research by US and German scientists.

The scientists found that using a small dose of the chemical tetrandrine, but not the herb itself, stopped the virus from replicating and protected mice from the disease without obvious side effects.

The discovery of the promising drug therapy against Ebola is announced in the journal Science.

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Pandemic Disease: Never again

As the Ebola epidemic draws gradually to its close, how should the world arm itself against the risks of insurgent infections?

 THE ECONOMIST                                                                                        March 21,  2015

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Ebola Diaries: Hitting the Ground Running

INFECTION CONTROL TODAY                                      March 24, 2015
The World Health Organization (WHO) is publishing a series, "Ebola Diaries," with first-person accounts of WHO staff and others deployed to the field for Ebola response since the first cases were reported in West Africa on March 23, 2014.
 
Dr. Stéphane Hugonnet, team lead for gobal capacities, alert and responses for the World Health Organization (WHO), was one of the first WHO experts sent to Guinea to investigate cases of Ebola reported in late March 2014. A medical doctor who has spent the past 20 years working for WHO, MSF and others, managing outbreaks ranging from cholera, measles and yellow fever, to Lassa, Ebola and meningitis, Hugonnet found a very different sort of outbreak when he arrived in Guinea.

"We were following this rumor of a small cluster of unexplained deaths in Guinea," he says. "Some thought it could be Lassa    phane fever, but the transmission pattern was very compatible with Ebola. When the lab results came back, we learned that there was Ebola Zaire in West Africa.            

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Fighting Ebola with a holistic vision of big data

TECH REPUBLIC  by Mary Shaklett                                                                         March 24, 2015

Big data practitioners are learning that the laboratory know-how of computer scientists and statisticians must be matched with a holistic, 360-degree vision of the problem to be solved. TheEbola crisis is a prime example....

If big data is going to help solve health issues like Ebola, it must be incorporated into analytics that consider all of the factors shaping the epidemic. These are three of the ingredients that should be factored into Ebola analytics.

1: There are political barriers that stand in the way of obtaining data from cell phone providers that could assist researchers in determining where the disease will strike next.

2: Even if disease researchers could obtain this data, there is a need to "correct" the data for what it doesn't reveal. For example, if less than 50% of a country's population has access to mobile phones and individuals are constantly moving from village to village, how will researchers be able to verify the quality of the data they're getting unless there are people "on the ground" who can verify or provide corrective factors to the data?

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Deconstructing “Malaria”: West Africa as the Next Front for Dengue Fever Surveillance and Control

sciencedirect.com - June 2014
Justin Stoler, Rawan al Dashti, Francis Anto, Julius N. Fobil, Gordon A. Awandare
doi:10.1016/j.actatropica.2014.02.017

CLICK HERE - Deconstructing “Malaria”: West Africa as the Next Front for Dengue Fever Surveillance and Control

Highlights

• Febrile illnesses are vastly overdiagnosed as malaria in many African settings.
• West Africa is emerging as a new front for dengue fever surveillance and control.
• Efficient health care utilization depends upon proper diagnosis of febrile illness.

Abstract

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Mistakes That Fueled Ebola Spread Are Preventing Its Containment One Year Later

REUTERS by Emma Farge                                             March 23, 2015

DAKAR, March 23 -- Lapses that fueled the Ebola outbreak after it was first discovered a year ago are dogging the final stages of the fight against the virus as fatigue and complacency set in, delaying the end of the deadly epidemic.

A man is sprayed with disinfectant after he celebrated the memory of a loved one who died due to the Ebola virus at a newly build grave yard for Ebola virus victims in Monrovia, Liberia, Wednesday, March 11, 2015. Liberians held a church service Wednesday for families who lost members to Ebola to mark the country’s 99th celebration National Decoration Day, a holiday normally set aside for people to clean up and re-decorate the graves of their lost relatives. (AP Photo/Abbas Dulleh) | ASSOCIATED PRESS

Three doctors were discovered to be infected with Ebola at a hospital in Guinea's capital Conakry last week in what health reports and government officials blamed on a failure to implement basic measures for infection control.

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As Ebola Crisis Ebbs, Aid Agencies Turn To Building Up Health Systems

NATIONAL PUBLIC RADIO by Nurith Aizenman                March 23, 2015

Recruiting and training new health workers is key, because experts warn that unless the health systems in West Africa are brought up to scratch, an epidemic on the scale of this one will happen again.

A nurse walks near the empty children's ward at Redemption Hospital in New Kru Town, Monrovia, Liberia. David Gilkey/NPR

Unfortunately, building national health systems doesn't tend to attract a lot of love from international donors, says Erin Hohlfelder, who's been pushing for this kind of funding on behalf of the ONE Campaign, a global health advocacy group.

"It's certainly not as 'sexy' — quote unquote — as things like treatment for HIV or bed nets for malaria, which are very tangible and easy to understand."

She says at least for now, the international community does seem to get the importance of building up West Africa's health systems. The governments of the affected countries are preparing national plans to present at a meeting of the World Bank next month

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Guinea Trial Begins for Suspected Killers of Ebola Workers

ASSOCIATED PRESS by Boubacar Diallo                    March 23, 2015

The trial highlights the challenges health workers faced in this Ebola outbreak that has claimed more than 10,000 lives, mostly in the impoverished West African nations of Guinea, Sierra Leone and Liberia.

Around 78 suspects are being tried in the town of N'Nzerekore, 900 kilometers (560 miles) from the capital Conakry, Ministry of Justice spokesman Ibrahima Beavogui said.

The killings happened when a delegation of health care workers, including top health officials from the nearby town, visited Womey last September to raise awareness about how to combat Ebola. They were attacked by a mob armed with knives and stones.

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Ebola outbreak 'over by August', UN suggests

BBC   by  Smitha Mundasad                                                                                        March 23, 2015

The Ebola outbreak in West Africa will be over by August, the head of the UN Ebola mission has told the BBC.

 

 Ismail Ould Cheikh Ahmed admitted the UN had made mistakes in handling the crisis early on, sometimes acting "arrogantly".

A year after the outbreak was officially declared, the virus has killed more than 10,000 people...

The head of the UN Ebola response mission told the BBC, when the virus first struck, "there was probably a lack of knowledge and there was a certain degree of arrogance, but I think we are learning lessons.

"We have been running away from giving any specific date, but I am pretty sure myself that it will be gone by the summer."

Read complete story.
http://www.bbc.com/news/health-32009508

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Slow International Response to Ebola Epidemic Cost Thousands of Lives: MSF

TIME MAGAZINE  by Helen Regan                                March 23, 2015
(Scroll down for link to full MSF report.)

Paris-based Doctors Without Borders (MSF) has slammedthe international community’s slow response to the Ebola outbreak in West Africa, saying it cost thousands of lives that could otherwise have been saved.

A Doctors Without Borders (MSF), health worker in protective clothing carries a child suspected of having Ebola in the MSF treatment center on October 5, 2014 in Paynesville, Liberia.

The leading international medical charity released a report Monday coinciding with the one-year anniversary of the outbreak’s start. It said warnings that the disease’s spread was out of control were dismissed as alarmist and that early calls for help were ignored by local governments and the World Health Organization (WHO), reports Reuters.

“For the Ebola outbreak to spiral this far out of control required many institutions to fail. And they did, with tragic and avoidable consequences,” said MSF’s general director Christopher Stokes in the report.

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