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Ending the Ebola Outbreak

Months of declining cases have fed hopes that the Ebola outbreak might finally be ending. “There are now 10 times fewer people diagnosed with Ebola each week than there were in September last year,”said Dr. David Nabarro, the United Nation’s special envoy on the Ebola crisis.

The number of new Ebola cases fell rapidly in December and January, but officials with the United Nations and the World Health Organization cautioned that ending the outbreak entirely would be extremely difficult.

“The outbreak still presents a grave threat,” Dr. Nabarro said. “We have to really work hard to get to what we call zero-zero — zero cases, zero transmissions.”

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Ebola endemic risk remains in west Africa, scientists warn

THE GUARDIAN      by Sarah Boseley                                                                         Feb. 25, 2015
 Scientists are warning of a real risk that the Ebola virus disease could become endemic in west Africa if efforts to end the epidemic slacken as the number of cases falls.

 All previous outbreaks of Ebola were stamped out within months and the virus disappeared from the human population each time. Guinea, Sierra Leone and Liberia, however, have been in the grip of the virus for more than a year. While the numbers of cases dropped dramatically in December and early January, they have now plateaued and there are fears that the disease may not be totally eradicated....

Dr Margaret Harris in the director general’s office of the World Health Organisation said they were at “a bump in the road”.

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Fear of Ebola's sexual transmission drives abstinence, panic

REUTERS                                                            Feb. 25, 2015

 MONROVIA --Musa Pabai left an Ebola treatment centre in Liberia in November, grateful to have survived a disease that has killed nearly 10,000 people across West Africa but fearing he still could pose grave danger the person closest to him.

 

People await medical treatment in the outpatient lounge of Redemption Hospital, formerly an Ebola holding center, on February 2, 2015 in Monrovia, Liberia. Most hospitals and clinics have re-opened, as the Ebola epidemic wanes.
Image by: John Moore / Getty Images.

By Valentine's Day, nearly three months later, the 23-year-old had not yet returned to Hannah, his girlfriend and mother of his young son.

"I don't want to be tempted by her ... It would be a problem," he said in the capital Monrovia, where he spent his self-imposed exile, afraid that he could still infect her through sexual contact despite his clean bill of health.

Research has shown traces of Ebola in semen of some survivors for at least 82 days after the onset of symptoms and in vaginal secretions for a much shorter period.

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First Ebola survivors talk of hope and despair in Guinea

What it was like for two survivors of Ebola in Guinea

REUTERS By Misha Hussain                                                                                       Feb. 24, 2015

GUECKEDOU, Guinea (Thomson Reuters Foundation) - Lying in an Ebola treatment center in southeast Guinea, hidden behind thick plastic sheets and surrounded by nurses in yellow protective suits, Rose Komano feared she would not survive the virus that had robbed her of so many loved ones.

"Everyone before me had died, I was terrified," Komano recalled.

But the 18-year-old became the first person to beat Ebola in the region of Gueckedou, where the latest outbreak of the disease was initially detected in March 2014...

In the capital Conakry, survivor Dore Zorobo had no such luck when he and six colleagues were infected by a sick woman from Sierra Leone seeking treatment at Donka hospital, where he worked as a lab technician on blood samples.

"Ebola turned my life upside down," said Zorobo, 32, from Lola in southeast Guinea, who was infected through a small cut on his hand in June.

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Quick Test for Ebola - MIT

submitted by George Hurlburt

      

A new paper diagnostic device can detect Ebola as well as other viral hemorrhagic fevers in about 10 minutes. The device (pictured here) has silver nanoparticles of different colors that indicate different diseases. On the left is the unused device, opened to reveal the contents inside. On the right, the device has been used for diagnosis; the colored bands show positive tests.  Photo - Jose Gomez-Marquez, Helena de Puig, and Chun-Wan Yen

Simple paper strip can diagnose Ebola and other fevers within 10 minutes

CLICK HERE - Lab on a Chip - Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses

Massachusetts Institute of Technology (MIT) - eurekalert.org - February 24, 2015

CAMBRIDGE, MA -- When diagnosing a case of Ebola, time is of the essence. . .

. . . A new test from MIT researchers . . . The device, a simple paper strip similar to a pregnancy test, can rapidly diagnose Ebola, as well as other viral hemorrhagic fevers such as yellow fever and dengue fever. . .

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Ebola Crisis: Red Cross workers attacked as virus conspiracies create panic in Guinea

INTERNATIONAL BUSINESS TIMES by Elsa Buchanan                                           Feb.24 ,2015

Ebola health workers have been the victims of mob attacks across Guinea caused by false rumours spread by opposition politicians, international NGOs exclusively claimed to IBTimes UK.

Members of the French military check a medical centre at Conakry's International airport, on 19 January 2015(BINANI/AFP/Getty Images)

The latest of these rumours - that the Red Cross was intentionally spraying schoolchildren with the virus - spread chaos in the capital Conakry and the region of Faranah last week, resulting in violent attacks against the organisation workers.

On 19 February, the Prefect of Faranah, Kennett Guilavogui, announced seven people had been arrested for the dissemination of rumours and false or misleading news....

Local journalist, Macky Sow told IBTimes UK: "It is very difficult to prove these rumours are spread for political reasons, but there are many people who claim politicians are behind these rumours."

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6 Challenges to Stamping Out Ebola

Despite a recent sharp drop in the overall number of Ebola cases, the situation remains precarious in West Africa

NATURE MAGAZINE  by Declan Butler                                                                    Feb. 24, 2015
More than a year since the start of one of the worst public health crises in recent history, Ebola cases have been tumbling in West Africa. But the epidemic is far from over: the risk of flare ups and further geographical spread will remain until there are no new cases.

The ease in case numbers means that public-health countermeasures and resources can be shifted in many places, from curbing runaway outbreaks to aggressively targeting the remaining, often smaller outbreaks....

At the same time, there is a danger of complacency. Reducing the number of cases to zero demands identifying and breaking all new chains of transmission, a task that still faces major obstacles—not least the fast approaching rainy season.

Highlighting the precariousness of the current situation, on February 20, the officials leading the United Nations' Ebola response efforts warned that the gains of the past few months risked unravelling.

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2 leading Ebola vaccines appear safe, WHO says

ASSOCIATED PRESS by Maria Cheng                                                                                 Feb. 23, 2015

LONDON – The World Health Organization says the two leading Ebola vaccines appear safe and will soon be tested in healthy volunteers in West Africa.

After an expert meeting this week, WHO said there is now enough information to conclude that the two most advanced Ebola vaccines — one made by GlaxoSmithKline and the other licensed by Merck and NewLink — have "an acceptable safety profile."

In a press briefing Friday, Dr. Marie-Paule Kieny, who heads WHO's Ebola vaccine efforts, said "the cupboard (for Ebola vaccines) is filling up rapidly."

She said further trials in healthy people in West Africa, including health workers, are scheduled to start soon. Kieny added several other vaccines were being developed in the U.S., Russia and elsewhere.

Read complete story.
http://www.baxterbulletin.com/story/life/health/2015/02/23/leading-ebola-vaccines-appear-safe-says/23901829/

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Limited Promise in early results from Ebola drug trial

AFP                                                                                                                     Feb. 23, 2015
Los Angeles  - Early results from an Ebola trial using the experimental drug Avigan (favipiravir) showed Monday it was somewhat effective at saving lives if given early in the illness, but not later.

Early results from an Ebola trial using the experimental drug Avigan (favipiravir) show it is somewhat effective at saving lives if given early in the illness (AFP Photo/George Frey)

The antiviral treatment is being developed by the Japanese company Toyama Chemical, and has been shown safe and effective against some other viruses including influenza, West Nile and yellow fever.

An ongoing clinical trial in Guinea is testing the drug's use in patients with the Ebola virus, which causes severe vomiting, diarrhea and sometimes fatal bleeding.

Results from only 80 people are available so far, but they show that among those who received the drug early in their illness, 15 percent died of Ebola.

Read complete story.

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Funding to Fight Ebola: Not Too Little, but Definitely Too Late

Center for Global Development - cgdev.org -by Karen A. Grépin and Amanda Glassman - February 4, 2015

. . . In a new paper out today in the BMJ, Karen investigated the level and speed of the international response to the Ebola outbreak and contrasted it with the appeals made by international leaders to curb the spread of the disease. Contrary to widespread belief, Karen finds that, overall, the level of donations to the response were actually robust: as of December 31st, 2,104 donors had pledged almost $3 billion towards controlling the epidemic. Notably, this is actually larger than the official appeals for upwards of $1.5 billion. In addition, the data used underestimate total donations, in particular those given by the World Bank, which mobilized at least $1 billion in financing to help support affected countries.

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