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Ebola Death Rates Vary Widely by Age Group

LIVE SCIENCE       by

Young children who are infected with Ebola may be more likely to die from the virus than older children or adults who are infected, according to a new study.

 In the study, researchers examined Ebola cases in children younger than 16 during the current outbreak in Guinea, Liberia and Sierra Leone, and compared them with adult cases. They found that the outbreak's death rate has been higher among younger children than among older children and adults.

The disease has killed about 90 percent of infected children under age 1, and about 80 percent of kids ages 1 to 4 who have been infected. Older children who have been infected with Ebola may have a much better chance of surviving....

"The very youngest of children — neonates  —appear to have the worst outcomes from Ebola," study co-author Dr. Robert Fowler, an associate professor of critical-care medicine at the University of Toronto, said in a statement. (Neonates, or newborns, are babies younger than 1 month.)

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Strengthening the Detection of and Early Response to Public Health Emergencies: Lessons learned from, the Ebola outbreake

PLOS MEDICINE by Mark J. Siedner, Lawrence O. Gostin, Hilarie H. Cranmer,and John D. Kraemer                        March 24, 2015

In-depth paper on lessons learned from the West Africa Ebola outbreak

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WHO Ebola Situation Report - 25 March 2015

WHO  WEEKLY SITUATION REPORT                                         March 25, 2015

Summary 

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New Ebola trial vaccine 'safe': researchers

AFP                                                                                                   March 25, 2015

Paris - The latest in a string of candidate vaccines against the deadly Ebola virus was proven safe in an early trial in healthy adults in China, its developers said Wednesday.

 But while it triggered an antibody response in test subjects, further trials must be held to establish whether the drug actually protects against Ebola, they said.

Dubbed Ad5-EBOV, the vaccine is the first based on the strain of the Ebola virus behind the west African outbreak, according to a paper published in The Lancet medical journal.

Read complete story.
http://news.yahoo.com/ebola-trial-vaccine-safe-researchers-140735607.html;_ylt=AwrBJR6SwhJVFgkANl3QtDMD

Read Lancet article.

http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2815%2960553-0/abstract

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Study announces a durable vaccine for Ebola

MEDICAL EXPRESS                                                                                             March 25, 2015

A new study shows the durability of a novel 'disseminating' cytomegalovirus (CMV)-based Ebola virus (Zaire ebolavirus; EBOV) strategy that may eventually have the potential to reduce ebolavirus infection in wild African ape species.

These are western lowland gorillas, one of the great ape species threatened by Ebola. Credit: Copyright 2012 Chris Whittier

A cytomegalovirus (CMV)-based vaccine provides long-lasting protective immunity against Ebola virus, and has potential for development as a disseminating vaccine strategy to prevent ebolavirus infection of wild African ape populations.

The multi-institutional study is led by Dr Michael Jarvis at Plymouth University, and is published today, 25th March 2015, in Vaccine.

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A Chemical Within a Traditional Chinese Medicine Has been Found to Be Effective Against Ebola

      

Health workers in protective clothing speak with new arrivals in the outpatient waiting room of Redemption Hospital, formerly an Ebola holding centre, in Liberia.  John Moore/Getty Images

CLICK HERE - SCIENCE - REPORT - Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment

businessinsider.com.au - by Chris Pash - February 27, 2015

A chemical found in the Chinese herb known as Han Fang ji switches off the channels which the Ebola virus uses to enter and infect cells, according to research by US and German scientists.

The scientists found that using a small dose of the chemical tetrandrine, but not the herb itself, stopped the virus from replicating and protected mice from the disease without obvious side effects.

The discovery of the promising drug therapy against Ebola is announced in the journal Science.

(READ COMPLETE ARTICLE)

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Pandemic Disease: Never again

As the Ebola epidemic draws gradually to its close, how should the world arm itself against the risks of insurgent infections?

 THE ECONOMIST                                                                                        March 21,  2015

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Ebola Diaries: Hitting the Ground Running

INFECTION CONTROL TODAY                                      March 24, 2015
The World Health Organization (WHO) is publishing a series, "Ebola Diaries," with first-person accounts of WHO staff and others deployed to the field for Ebola response since the first cases were reported in West Africa on March 23, 2014.
 
Dr. Stéphane Hugonnet, team lead for gobal capacities, alert and responses for the World Health Organization (WHO), was one of the first WHO experts sent to Guinea to investigate cases of Ebola reported in late March 2014. A medical doctor who has spent the past 20 years working for WHO, MSF and others, managing outbreaks ranging from cholera, measles and yellow fever, to Lassa, Ebola and meningitis, Hugonnet found a very different sort of outbreak when he arrived in Guinea.

"We were following this rumor of a small cluster of unexplained deaths in Guinea," he says. "Some thought it could be Lassa    phane fever, but the transmission pattern was very compatible with Ebola. When the lab results came back, we learned that there was Ebola Zaire in West Africa.            

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Fighting Ebola with a holistic vision of big data

TECH REPUBLIC  by Mary Shaklett                                                                         March 24, 2015

Big data practitioners are learning that the laboratory know-how of computer scientists and statisticians must be matched with a holistic, 360-degree vision of the problem to be solved. TheEbola crisis is a prime example....

If big data is going to help solve health issues like Ebola, it must be incorporated into analytics that consider all of the factors shaping the epidemic. These are three of the ingredients that should be factored into Ebola analytics.

1: There are political barriers that stand in the way of obtaining data from cell phone providers that could assist researchers in determining where the disease will strike next.

2: Even if disease researchers could obtain this data, there is a need to "correct" the data for what it doesn't reveal. For example, if less than 50% of a country's population has access to mobile phones and individuals are constantly moving from village to village, how will researchers be able to verify the quality of the data they're getting unless there are people "on the ground" who can verify or provide corrective factors to the data?

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Deconstructing “Malaria”: West Africa as the Next Front for Dengue Fever Surveillance and Control

sciencedirect.com - June 2014
Justin Stoler, Rawan al Dashti, Francis Anto, Julius N. Fobil, Gordon A. Awandare
doi:10.1016/j.actatropica.2014.02.017

CLICK HERE - Deconstructing “Malaria”: West Africa as the Next Front for Dengue Fever Surveillance and Control

Highlights

• Febrile illnesses are vastly overdiagnosed as malaria in many African settings.
• West Africa is emerging as a new front for dengue fever surveillance and control.
• Efficient health care utilization depends upon proper diagnosis of febrile illness.

Abstract

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