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Ebola likely to persist in 2015 as communities resist aid: Red Cross

REUTERS  by  Stephanie Nebehay                                                                                   Jan. 30, 2015

GENEVA --West Africa will be lucky to wipe out Ebola this year, as the local population remains suspicious of aid workers, especially in Guinea, the Red Cross said on Friday.

 

 Healthcare workers prepare to disinfect an ambulance transporting a newly admitted Ebola patient at the entrance to the Save the Children Kerry Town Ebola treatment centre outside Freetown, Sierra Leone in this file photo taken on December 22, 2014. Credit: Reuters/Baz Ratner

The virus is "flaring up" in new areas in the region and not all infections are being reported, said Birte Hald, who leads the Ebola coordination and support unit of the International Federation of Red Cross and Red Crescent Societies.

"We are also seeing that in places like Sierra Leone and especially in Guinea that it is flaring up in new districts all the time, with small new chains of transmission, which means that it's not under control and it could flare up big-time again," Hald told a news briefing in Geneva.

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How Bad Data Fed the Ebola Epidemic

      

Daniel Berehulak for The New York Times

nytimes.com - By RACHEL GLENNERSTER, HERBERT M’CLEOD and TAVNEET SURI - January 30, 2015

. . . Valid, credible and timely data is essential during a global crisis. Without reliable data, efforts to assist affected people and to rebuild damaged communities can be misdirected and inefficient. . .

The West African Ebola outbreak first hit Sierra Leone in May 2014, followed by an explosion of cases in the capital Freetown in the autumn. . .

The early days of the crisis were characterized by a sense of immense fear, anxiety and alarm, regionally and globally. .

Misleading reports, speculation and poor projections from international agencies, government ministries and the media about the Ebola outbreak exacerbated the problem.

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Global Health Security: The Next Five Years

onlinedigeditions.com - Andrew C. Weber - Christine Parthemore

The next five years will see crucial changes in the global health security landscape, profoundly shaped by two key events in 2014:

The Ebola response in West Africa, and the successful first year of the Global Health Security Agenda, an initiative of dozens of countries and non-governmental organizations to make tangible commitments for preventing, rapidly detecting, and effectively responding to infectious disease threats.(1) 

Both events brought to light signs of measurable progress, and profound gaps that must be prioritized in the years ahead. Pressing needs include expanding emergency operations center capacity, better leveraging technological innovation, and closing the gap between the health and security communities.

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Do Ebola educators make a difference?

THE GUARDIAN by                        Jan. 29. 2015

FREETOWN, Sierra Leone -- The initial Ebola case in Tambakha [a remote chiefdom near the Guinea border] coincided with the proper training of the first set of Ebola educators. They were deployed in mid-October to educate local people on the prevention and control of Ebola and to help monitor the advent of newcomers into their communities, possible carriers.

 

Health workers conduct a campaign raising awareness of the Ebola virus in Freetown, Sierra Leone. Photograph: Tanya Bindra/EPA

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Botswana Doctor Is Named to Lead W.H.O. in Africa

NEW YORK TIMES  by Donald G. McNeil, Jr.                                                               Jan. 27, 2015

A defining moment in the life of Dr. Matshidiso Moeti, the World Health Organization’s new regional director for Africa, came when she was 9 and her father realized that her little sister’s mathematics textbook was below even the level he had studied as a poor child on a South African farm.

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Weekly Ebola cases below 100, WHO says endgame begins

REUTERS  by Tom Miles and Stephanie Nebehay               Jan. 29, 2015

The number of new confirmed Ebola cases totaled 99 in the week to Jan. 25, the lowest tally since June 2014, the World Health Organization said on Thursday, signaling the tide might have turned against the epidemic.

"The response to the EVD (Ebola virus disease) epidemic has now moved to a second phase, as the focus shifts from slowing transmission to ending the epidemic," the WHO said.

"To achieve this goal as quickly as possible, efforts have moved from rapidly building infrastructure to ensuring that capacity for case finding, case management, safe burials, and community engagement is used as effectively as possible."

But Guinea reported 30 confirmed cases in the latest week, up from 20 in the previous week. The epidemic is also still spreading geographically there, with a first confirmed case in Guinea's Mali prefecture bordering Senegal, which reopened its border with Guinea on Monday.

Read complete story.

http://www.reuters.com/article/2015/01/29/us-health-ebola-idUSKBN0L20U320150129

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Ebola outbreak: Virus mutating, scientists warn

Scientists tracking the Ebola outbreak in Guinea say the virus has mutated.

Researchers at the Institut Pasteur in France, which first identified the outbreak last March, are investigating whether it could have become more contagious.

They are tracking how the virus is changing and trying to establish whether it's able to jump more easily from person to person

"We know the virus is changing quite a lot," said human geneticist Dr Anavaj Sakuntabhai.

It's not unusual for viruses to change over a period time. Ebola is an RNA virus - like HIV and influenza - which have a high rate of mutation. That makes the virus more able to adapt and raises the potential for it to become more contagious.

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http://www.bbc.com/news/health-31019097

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There's an Ebola Vaccine in Africa. Now What?

A scanning electron micrograph of the Ebola virus. The first large-scale trials of an Ebola vaccine are underway in Africa.(NIAID / Flickr)

Unprecedented: In four months, the Ebola vaccine has gone from concept to field trial. Success is not assured.

 THE NATIONAL JOURNAL  by Brian Resnick                      Jan. 28, 2015

Detailed description of the problems issues and procedures for fieldingand testing Ebola vaccines in West Africa.

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..."Without the (Ebola) virus circulating, there's no way to prove the vaccine is effective. At current infection rates, trial researchers would need to see 100 cases of Ebola over a four-month period to achieve statistical significance. That time frame may stretch, or fall apart altogether.

"It's a real dilemma," says Margaret Harris, an MD and spokeswoman for the World Health Organization. "It's extremely good news that the cases are coming down, but it does mean we may not have clear phase III data."

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An experimental Ebola vaccine looks promising in a human trial

Vaccine  was made by introducing an Ebola gene in a chimpanzee cold virus

THE VERGE    by Arielle Duhaime-Ross                                                             Jan. 28, 2015

An Ebola vaccine produced using a chimpanzee common cold virus appears to be safe to use on humans, according to a study published today in the New England Journal of Medicine. Three different doses of vaccine were tested on healthy humans in the UK, and it was well-tolerated; it triggered high levels of antibody formation without also triggering serious side effects. But until the vaccine is tested in an area where an Ebola risk actually exists, it’s efficacy against the disease will remain a mystery.

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http://www.theverge.com/2015/1/28/7930947/ebola-vaccine-human-trials-results

A Monovalent Chimpanzee Adenovirus Ebola Vaccine — Preliminary Report

 New England Journal of Medicine

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WHO - Resolution - Executive Board Special Session on Ebola

                                        

CLICK HERE - WHO - Resolution - Ebola: Ending the current outbreak, strengthening global preparedness and ensuring WHO capacity to prepare for and respond to future large-scale outbreaks and emergencies with health consequences (11 page .PDF report)

CLICK HERE - Executive Board Special Session on Ebola - Additional supporting documentation

chathamhouse.org - by Dr. Charles Clift - January 27, 2015

The executive board of the World Health Organization (WHO) agreed a comprehensive resolution on its response to the Ebola crisis in a special session on 25 January. After the WHO was widely criticized for its perceived inadequacies in dealing with the Ebola outbreak in West Africa, the resolution asks for a transformation in the way the organization works in health emergencies. The WHO admits there is substance in these criticisms – with Margaret Chan, WHO’s director-general (DG), acknowledging shortcomings in WHO’s ‘administrative, managerial and technical infrastructures’.

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