COVID boosters offer good protection against severe outcomes but less so against the now dominant strain, JN.1

Current COVID boosters offer good protection against severe outcomes but less so against JN.1 The current COVID-19 boosters targeting the Omicron XBB.1.5 subvariant are still offering solid protection against infection, hospitalizations, and death, but are somewhat limited in efficacy against illnesses caused by the JN.1 subvariant, now the dominant strain in the United States, according to a research letter yesterday in the New England Journal of Medicine. CIDRAP

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The authors said the findings underscore the need for new boosters. Next week, the Center for Disease Control and Prevention's VRBPAC (Vaccines and Related Biological Products Advisory Committee) will meet to select COVID and influenza strains to include in updated vaccines.

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