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Study Blocks Ebola Virus Budding By Regulating Calcium Signalling
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Study Blocks Ebola Virus Budding By Regulating Calcium Signalling
Fri, 2015-11-27 18:45 — Kathy Gilbeauxsubmitted by George Hurlburt
scicasts.com - November 2, 2015
Philadelphia, PA (Scicasts) — The Ebola virus acts fast. The course of infection, from exposure to recovery, or death, can take as little as two weeks. That may not leave enough time for the immune system to mount an effective response.
The goal of some anti-viral therapies, therefore, is to buy more and give the immune system a leg up on the virus. A new study led by Bruce Freedman and Ronald Harty in the Department of Pathobiology of the University of Pennsylvania School of Veterinary Medicine demonstrates a way to do that, by reducing the ability of the virus to exit a host cell and spread. Their work showed that blocking a calcium-signalling pathway could inhibit not only the Ebola virus, but also Marburg, Lassa and Junin viruses, all sources of deadly infections.
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