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Two experimental Ebola vaccines pass safety test in African trial

REUTERS    by  Sharon Begley                                                                       March 26, 2015

NEW YORK - Two experimental Ebola vaccines, one from GlaxoSmithKline PLC and the other from biotech start-up NewLink Genetics Corp, "appear to be safe" part way through a clinical trial being conducted in Liberia, the U.S. National Institutes of Health (NIH) said on Thursday.

The two vaccines, each given in a single injection, are being tested for safety and efficacy on more than 600 people in Liberia in a mid-stage clinical trial sponsored by the National Institute of Allergy and Infectious Diseases, a branch of NIH.

The Ebola epidemic that began in West Africa one year ago has killed more than 10,200 people, but a decline in new cases in the most affected countries, Liberia, Guinea and Sierra Leone, has led to hopes that it may be ending.

Based on the encouraging safety results, the study may now advance to the next phase of efficacy testing, in which additional volunteers are injected with the GSK vaccine, the NewLink vaccine, or a dummy shot and assessed to see whether their immune system responds by producing anti-Ebola antibodies.

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How Did Ebola Volunteers Know Where To Go In Liberia? Crowdsourcing!

NATIONAL PUBLIC RADIO  by Poncie Rutsch                                                      March 25, 2015
From more than 900 miles away, Kpetermeni Siakor helped get volunteers to the right neighborhoods in his native Liberia during the height of the Ebola epidemic.

Kpetermeni Siakor (left), a Liberian who is studying in Ghana, used crowdsourcing software to help out during the Ebola epidemic. Courtesy of Ashesi University College

He did it with Ushahidi, crowdsourcing software that was developed in Kenya in 2008, when the country experienced a wave of post-election violence. The word Ushahidi means testimony in Swahili.

"The government had shut down internet connections and radio stations, so Ushahidi was born out of the need to let people know what is happening," says Siakor, 26. He's a computer science student at Ashesi University College in Accra, Ghana, and receives financial support from the MasterCard Foundation Scholars Program.

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Dr. Gavin Macgregor-Skinner - Ebola - Health Organizations Slow to Respond

      

CLICK HERE - RECORDED VIDEO - Dr. Gavin Macgregor-Skinner

ctvnews.ca - March 23, 2015

Public health emergency expert Dr. Gavin Macgregor-Skinner discusses a new report saying faster action would have stopped the spread of Ebola.

CLICK HERE - MSF REPORT AND RELATED INFORMATION

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Ebola Vaccine Trial Starts in Guinea

TIME MAGAZINE  by Alexandra Sifferlin                                             March 25, 2015
An efficacy trial for an Ebola vaccine launched in Guinea on Wednesday.

 

 A health worker prepares a vaccination on March 10, 2015 at a health center in Conakry during the first clinical trials of the VSV-EBOV vaccine against the Ebola virus.

The vaccine, VSV-EBOV, was developed by the Public Health Agency of Canada and has already shown positive results in smaller safety trials. NewLink Genetics and Merck are collaborating on the vaccine, and the Guinean government and World Health Organization (WHO) are leading the trial, which is taking place in Basse-Guinée, a community where many Ebola cases spread.

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Fighting cancer and Ebola with nanoparticles

CNN  by

In medicine, finding a substance that attacks cancerous tumors without destroying the healthy tissue around it has long been the Holy Grail.

From targeted remedies such as monoclonal antibodies to surgery, cancer has still managed to elude a treatment that discretely and separately attacks it alone.

Nanotechnologies, however - the manipulation of matter at a molecular and even atomic scale to penetrate living cells -- are holding out the promise of opening a new front against deadly conditions from cancer to Ebola.

According to Dr Thomas Webster, the chair of chemical engineering at Northeastern University in Boston, research into medical nanotechnology is gaining pace and the medical establishment is starting to sit up and pay attention.

Read complete story.

http://www.cnn.com/2015/03/25/tech/webster-nanoparticles-cancer-mci/

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Fighting cancer and Ebola with nanoparticles

CNN  by

In medicine, finding a substance that attacks cancerous tumors without destroying the healthy tissue around it has long been the Holy Grail.

From targeted remedies such as monoclonal antibodies to surgery, cancer has still managed to elude a treatment that discretely and separately attacks it alone.

Nanotechnologies, however - the manipulation of matter at a molecular and even atomic scale to penetrate living cells -- are holding out the promise of opening a new front against deadly conditions from cancer to Ebola.

According to Dr Thomas Webster, the chair of chemical engineering at Northeastern University in Boston, research into medical nanotechnology is gaining pace and the medical establishment is starting to sit up and pay attention.

Read complete story.

http://www.cnn.com/2015/03/25/tech/webster-nanoparticles-cancer-mci/

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Strengthening the Detection of and Early Response to Public Health Emergencies: Lessons learned from, the Ebola outbreake

PLOS MEDICINE by Mark J. Siedner, Lawrence O. Gostin, Hilarie H. Cranmer,and John D. Kraemer                        March 24, 2015

In-depth paper on lessons learned from the West Africa Ebola outbreak

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Study announces a durable vaccine for Ebola

MEDICAL EXPRESS                                                                                             March 25, 2015

A new study shows the durability of a novel 'disseminating' cytomegalovirus (CMV)-based Ebola virus (Zaire ebolavirus; EBOV) strategy that may eventually have the potential to reduce ebolavirus infection in wild African ape species.

These are western lowland gorillas, one of the great ape species threatened by Ebola. Credit: Copyright 2012 Chris Whittier

A cytomegalovirus (CMV)-based vaccine provides long-lasting protective immunity against Ebola virus, and has potential for development as a disseminating vaccine strategy to prevent ebolavirus infection of wild African ape populations.

The multi-institutional study is led by Dr Michael Jarvis at Plymouth University, and is published today, 25th March 2015, in Vaccine.

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Pandemic Disease: Never again

As the Ebola epidemic draws gradually to its close, how should the world arm itself against the risks of insurgent infections?

 THE ECONOMIST                                                                                        March 21,  2015

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The Ebola detectives

The BBC   by Hans Rosling                                                                    March 23, 2015
Interview with Swedish statistician and global health professor Hans Rosling who spent three months working as an epidemiologist in the Liberian Health Ministry helping to tackle the Ebola crisis.

 

                  Hans Rosling flanked by Maj Morris Hunh (China), to his right, and Gen Gary Volesky(U.S.) to his left

Excerpt from BBC interview:

The curve turned around because enough Ebola treatment units were built. Medecins Sans Frontieres ran the biggest. When that was not enough, Liberian doctors and nurses added the next treatment unit. But the race against time in September to provide treatment and isolation for all patients, when the epidemic curve climbed to 30, 40 and 50 patients per day, was won by the WHO.

 By the end of September, Dr Atai from Uganda opened the so-called Island Clinic which meant beds could be offered to all Ebola patients.The curve was curbed for four reasons:

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