OPINION: Beyond COVID-19—a paradigm shift in infection management?

The health and economic impact of multidrug-resistant (MDR) bacteria has continuously grown over the past years, reaching an estimated peak of approximately 700 000 attributable deaths per year.

 

Neglected hygiene, poor compliance with infection control procedures, inappropriate antimicrobial use, and insufficient availability of diagnostics and new effective antibiotics have contributed to this inglorious global record.

 

Despite these alarming figures, infection prevention and treatment have not been considered top priorities on the agendas of most industrialised countries.

 

This mindset changed abruptly with the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

The exponential expansion of the pandemic catapulted COVID-19 to the top of national and international priority lists, and people judge the performance of their political leaders on the basis of success in containing the pandemic. The more we realise how much SARS-CoV-2 has changed the world, the more we question the suitability of our prevention, management, and drug development strategies with respect to other major pathogens.

 

Notably, the population at risk of severe COVID-19, including elderly, immunocompromised, and multimorbid people, largely overlaps with the population at risk of health-care-associated infections (HAIs). Even among high-income countries, there are substantial differences in MDR infection rates, varying between close to zero and more than 50% depending on national strategies and health economic investments. ...

 

The pandemic has changed our ways of thinking and paved the way for more efficient measures against other types of infections; we have learned to deal with epidemiological big data more efficiently, new research networks for innovative research are in place, venture capital will be more easily available for development programmes, and public opinions will back stronger governmental commitments to tackling HAIs.

 

The time has come for a paradigm shift in infection management.