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Tekmira Inks Deal to Test New Ebola Drug in Humans

GENOMEWEB                                                                                                                        Dec. 22, 2014
NEW YORK -- Tekmira Pharmaceuticals announced today that it has signed a deal that will support the clinical testing of its experimental Ebola therapy designed against the strain of the virus behind the outbreak in West Africa.

Tekmira has long been developing an siRNA-based Ebola drug called TKM-Ebola, but a Phase I study of that agent was suspended by US regulators until the company could provide additional safety data. Earlier this year, Tekmira management indicated that that trial might not restart as early as anticipated since the firm had begun focusing on a version specifically for the Guinea strain of the Ebola virus, which is driving the ongoing outbreak.

Tekmira said it has now inked a manufacturing and clinical trial agreement with the University of Oxford to provide the new drug, called TKM-Ebola-Guinea, for clinical trials in West Africa. The university is the representative of the International Severe Acute Respiratory and Emerging Infection Consortium, which will be testing TKM-Ebola-Guinea in infected individuals with funding from the Wellcome Trust.

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Can the blood of Ebola survivors create a cure?

REUTERS       by  Julie Steenhuysen                                                                                 Dec. 22, 2014
CHICAGO --For months, Vanderbilt University researcher Dr. James Crowe has been desperately seeking access to the blood of U.S. Ebola survivors, hoping to extract the proteins that helped them overcome the deadly virus for use in new, potent drugs.

Blood samples from patients suspected of having the Ebola virus disease are prepared for transportation to Freetown for testing, at the Port Loko District Hospital September 27, 2014. Credit: Reuters/Christopher Black/WHO/Handout via Reuters

His efforts finally paid off in mid-November with a donation from Dr. Rick Sacra, a University of Massachusetts physician who contracted Ebola while working in Liberia. The donation puts Crowe at the forefront of a new model for fighting the virus...

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DoD extends review of Ebola quarantine policy

MILITARY TIMES By Andrew Tilghman                                                                                Dec. 19, 2014
Thousands of troops deployed to West Africa to help contain the Ebola virus will have to wait a few more weeks to find out whether the policy of 21-day quarantines after their redeployment will continue, military officials said.

The Pentagon has granted an extension on the deadline for reviewing the controversial rule requiring a 21-day, post-deployment quarantine. The review will now be completed by Jan. 30, 2015.

When Defense Secretary Chuck Hagel announced the quarantine on Oct. 29, he ordered military officials to conduct a review within 45 days to determine whether it was effective and necessary.

That review was due on Dec. 12, but Hagel granted a seven-week extension following a request from the chairman of the Joint Chiefs, Army Gen. Martin Dempsey.

Read complete story.
http://www.militarytimes.com/story/military/pentagon/2014/12/19/ebola-quarantine-review/20637663/?utm_source=December+22+2014+EN&utm_campaign=12%2F22%2F2014&utm_medium=email

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IMF policies blamed for Ebola spread in West Africa

BBC                                                                                                                       Dec. 22 2014

Spending cuts imposed by the International Monetary Fund (IMF) may have contributed to the rapid spread of Ebola in three West African states, UK-based researchers say.

                      Sierra Leone, along with Liberia and Guinea, have poor health facilities

It had led to "under-funded, insufficiently staffed, and poorly prepared health systems" in Sierra Leone, Liberia and Guinea, they said.

The IMF denied the allegation.

"A major reason why the Ebola outbreak spread so rapidly was the weakness of healthcare systems in the region, and it would be unfortunate if underlying causes were overlooked," said Cambridge University sociologist and lead study author Alexander Kentikelenis....

The IMF said in a statement that health spending in Guinea, Liberia and Sierra Leone had, in fact, increased in the 2010-2013 period.

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Ebola Should Be Easy to Treat

NEW YORK TIMES SUNDAY REVIEW   by Jeffrey Gettleman                                            Dec. 21, 2014

FREETOWN, Sierra Leone --
...Ebola, however much some of its symptoms conjure up a horror film, is usually shockingly simple to treat. The virus is swift and ruthless, hideous and creepy, causing some patients to have bloody vomit, bloody diarrhea or even — in severe cases — bloody eyeballs. Ebola is one of the handful of viruses than can trigger a hemorrhagic fever, with internal bleeding, but in most cases the biggest threat is dehydration, which can be addressed by clean water and basic drugs.

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Ebola death toll close to 7,400, says World Health Organisation

The Guardian    by Chris Johnston                                        Dec. 20, 2014

(Two items, scroll below.)

FREETOWN, Sierra Leone --The death toll from the worst ever outbreak of Ebola has reached nearly 7,400, with just over 19,000 people infected across west Africa, according to the World Health Organisation (WHO).

The UN secretary general, Ban Ki-moon, addresses health workers in Sierra Leone. Photograph: Evan Schneider/AFP/Getty Images

Sierra Leone reported 400 new fatalities this week, bringing the death toll there to 2,500. As of 18 December, it had the highest number of people infected by the virus – 8,800 cases, of which 6,900 were confirmed, according to the country’s health ministry.

The WHO is attempting to curb an outbreak in the west of the country, where the disease is spreading fastest, by sending a “massive surge of staff and resources” to the area.

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UN's Ban urges end to discrimination against Ebola workers

REUTERS --By Matthew Mpoke Bigg                                 Dec.20, 2014
CONAKRY--U.N. Secretary-General Ban Ki-moon on Saturday urged countries affected by the Ebola virus to avoid discriminating against healthcare workers fighting to end the disease.

U.N. Secretary General Ban Ki-moon has his temperature checked upon arrival at the Roberts International airport in Liberia's capital Monrovia December 19, 2014. Credit: Reuters/James Giahyue

Ban was speaking in Guinea on the second day of a whistle-stop tour aimed at thanking healthcare workers of the countries at the heart of the epidemic....

Ban's tour began in Liberia and Sierra Leone on Friday and will end later on Saturday in Ghana, site of the U.N. Ebola response mission (UNMEER), after a visit to Mali.

"There should be no discrimination for those who have been working or helping with Ebola. Those people are giving all of themselves," Ban told U.N. officials in Conakry.

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Ebola-Stricken Families to Receive Cash Payments

TIME MAGAZINE by ALexandra Sifferlin                                                                            Dec. 19, 2014

In 2015, the three Ebola-affected countries will start offering cash payments for families hit by Ebola, as well as survivors having trouble re-acclimating to society out of stigma for the disease.

Dudu Kromah’s husband died from Ebola. She is looking after ten children, many of them orphans including a 3-month-old baby. She has no income. Carly Learson—Carly Learson / UNDP

Every aspect of Guinea, Liberia and Sierra Leone’s societies have taken a hit from Ebola, and the disease has shocked what were once fragile but growing economies....Every aspect of Guinea, Liberia and Sierra Leone’s societies

“We are seeing a backwards slide of development of about 10 years,” says Boaz Paldi, chief of media and advocacy at the United Nations Development Programme (UNDP). “The outlook is not good. We are fearful for these countries.”

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CSIS Podcast - Ebola in West Africa

csis.org - Center for Strategic and International Studies

The CSIS podcast “Ebola in West Africa” has been named by Apple as one of its “Best of 2014” podcasts on iTunes U.

“Ebola in West Africa” was produced by Sahil Angelo, a young professional who works in the CSIS Global Health Policy Center in conjunction with our team of multi-media professionals in the CSIS Ideas Lab.

CSIS multimedia is available on iTunes, iTunes U and on www.CSIS.org/multimedia

CLICK HERE - iTunes - Ebola in West Africa

CLICK HERE - Tweet - iTunes U - Best of 2014

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Ebola: limitations of correcting misinformation

THE LANCET                                                                                                              Dec.18, 2014
Communication and social mobilisation strategies to raise awareness about Ebola virus disease and the risk factors for its transmission are central elements in the response to the current Ebola outbreak in west Africa.1 A principle underpinning these efforts is to change risky "behaviour" related to "traditional" practices and "misinformation".

 Populations at risk of contracting Ebola virus disease have been exhorted to “put aside, tradition, culture and whatever family rites they have and do the right thing”....Such messages follow logically from clinical and epidemiological framings of contagion.

They pay little attention, however, to the historical, political, economic, and social contexts in which they are delivered....

Read the complete article.

http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2814%2962382-5/fulltext

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