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Neglected Tropical Diseases in the Ebola- Affected Countries of West Africa

PLOS   EDITORIAL by Peter J. Hotez, Sabin Vaccine Institute                          June 25, 2015
While global attention in West Africa is focused on the emergence of Ebola virus infection, new information from the published literature and World Health Organization databases reveals that many other neglected tropical diseases (NTDs) are far more widespread and also require urgent attention.
Well before Ebola virus infection emerged in West Africa at the end of 2013, the three
major affected countries--Guinea, Liberia, and Sierra Leone were already known to
be highly affected by NTDs....
Today, new information from the recent literature and the World Health Organization
(WHO) Preventive Chemotherapy and Transmission (PCT) Control databases reveals that
NTDs remain widespread in Guinea, Liberia, and Sierra Leone.  An estimated
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WHO Ebola Situation Report - June 24, 2015 | UNMEER External Situation Report - June 22, 2015

                  

who.int - June 24, 2015                                                                         ebolaresponse.un.org - June 22, 2015

CLICK HERE - WHO Ebola Situation Report - June 24, 2015

CLICK HERE - UNMEER External Situation Report - June 22, 2015 - (2 page .PDF file)

CLICK HERE - WHO Ebola Situation Reports

CLICK HERE - UN Mission for Ebola Emergency Response (UNMEER) Situation Reports

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Liberia: Flirting With Disaster - Porous Border, Close Ebola Recall

allafrica.com - Front Page Africa - by Bettie Johnson - June 22, 2015

. . . The country is now in a panic mode after a sick lady from neighboring Guinea was intercepted by security officers at a checkpoint deep inside Liberian territory, raising fears that the episode of 2014 which brought Ebola to Liberia is threatening to reemerge. . . .

. . . A Global Communities Surveillance Officer disclosed that although they are carrying out temperature checks on commuters, people using illegal entry points are moving without going through health screening. . . .

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Ebola Returns to Sierra Leone Capital After Weeks of No New Cases

            

Health workers put on protective gear before entering a quarantine zone at a Red Cross facility in the town of Koidu, Kono district in Eastern Sierra Leone December 19, 2014.  REUTERS/BAZ RATNER

Cases found in a densely populated slum

time.com - Alexandra Sifferlin - June 22, 2015

Two new cases of the deadly Ebola virus have been recorded in Sierra Leone’s capital city of Freetown, about three weeks after the most recent new cases were found, underscoring the difficulty of ridding the region of the disease.

“This is worrisome because we had already closed all Ebola quarantine structures in Freetown since we had gone for weeks without a case,” Sidi Yahya Tunis, a spokesman for the National Ebola Response Centre (NERC) told Reuters. The cases were found in a densely populated slum called Magazine.

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Malaria morbidity and mortality in Ebola-affected countries caused by decreased health-care capacity, and the potential effect of mitigation strategies: a modelling analysis

LANCET by Patrick G. T. Walker and others                               Volume 15, No. 7, p825–832, July 2015
The ongoing Ebola epidemic in parts of west Africa largely overwhelmed health-care systems in 2014, making adequate care for malaria impossible and threatening the gains in malaria control achieved over the past decade. We quantified this additional indirect burden of Ebola virus disease.

We estimated the number of cases and deaths from malaria in Guinea, Liberia, and Sierra Leone from Demographic and Health Surveys data for malaria prevalence and coverage of malaria interventions before the Ebola outbreak. We then removed the effect of treatment and hospital care to estimate additional cases and deaths from malaria caused by reduced health-care capacity and potential disruption of delivery of insecticide-treated bednets. We modelled the potential effect of emergency mass drug administration in affected areas on malaria cases and health-care demand....

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Trial of Canadian Ebola drug stopped; no overall benefit shown

CANADIAN PRESS  by  Helen Branswell                       June 19, 2015

TORONTO -- A Canadian company that had been developing an Ebola drug says a clinical trial of the experimental product has been stopped.

Tekmira Pharmaceuticals says the trial was halted because it seemed clear that continuing was not likely to show that the drug works.

The drug is called TKM-Ebola. It was being tested with Ebola patients in Sierra Leone.

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http://www.ctvnews.ca/health/trial-of-canadian-ebola-drug-stopped-no-overall-benefit-shown-1.2430501

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Ebola showed aid delivery desperately needs an overhaul

REUTERS  by Stella Dawson                                                          JUNE 18, 2015

WASHINGTON -- The Ebola epidemic exposed long-standing holes in aid delivery,  which desperately needs an overhaul before the next international emergency hits, aid experts said on Thursday.

Supplies for the Ebola zone in West Africa wait to be loaded at New York's John F. Kennedy International Airport September 20, 2014. REUTERS/Carlo Allegri

Many of the shortcomings seen during the Haiti earthquake of slow responses and uncoordinated relief efforts were repeated during the Ebola crisis that erupted in West Africa a year ago, they said.

With Sierra Leone and Guinea continuing to report cases of the deadly virus, the international community must act urgently, said Carolyn Reynolds, external relations manager at the World Bank.

"We need to think outside the box," she said at a panel on global health preparedness held on Capitol Hill.

Read complete story.
www.trust.org/item/20150618215202-ilvea/?source=fiOtherNews2

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Ebola genetic code analysed to show evolution of worst ever outbreak

THE GUARDIAN   by Ian Sample                                                                             June 18, 2015

Scientists have analysed the genetic code of Ebola viruses from patients across west Africa and pieced together the evolution of the worst ever outbreak of the killer disease.

Experts from Public Health England at Porton Down in Britain, the World Health Organisation (WHO), and other leading labs, used DNA from 179 Ebola samples to reconstruct the spread of the virus from Guinea into surrounding countries last year.

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Why Some Ebola Strains Are More Dangerous Than Others

CHEMISTRY WORLD by Christopher Barnard             June 17, 215
The virulence of Ebola virus strains appears to be innately linked to the degree of disorder in proteins that form their nucleocapsids. Computational analysis has revealed that strains responsible for the most lethal outbreaks of Ebola show significantly higher levels of intrinsic protein disorder than less virulent strains, in a discovery that could constitute a major breakthrough in understanding the pathogen’s behaviour.

With over 27,000 confirmed, probable and suspected cases and more than 11,000 fatalities worldwide, the ongoing Ebola outbreak has resulted in considerably more casualties since late 2013 than all other outbreaks combined. There are no effective treatments or vaccines against the haemorrhagic fever that evinces Ebola infection; however, strains of the virus with drastically different virulence have emerged since the first outbreak in 1976, with fatality rates ranging from 25 to 90%.

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Sierra Leone: Mothers Refuse to Vaccinate Children for Fear of Resurgent Ebola

BREITBART.COM  by Frances Martel                                             June 16, 2015

Doctors in Port Loko, a northwestern region of Sierra Leone outside Freetown, are reporting a significant drop in the number of mothers bringing their children to hospitals for routine vaccinations. The mothers, they say, fear exposing their children to a resurgent Ebola virus, and in keeping them from hospitals are risking triggering the spread of polio or measles.

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