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Ebola vaccines in limbo expose need for more speed in trials

REUTERS by Kate Keller and Ben Hirschler                                      June 17, 2015

LONDON --Drugmakers' plans to conduct vast clinical trials to test and hopefully validate the first Ebola vaccines have been thwarted by success in beating back the deadly epidemic in West Africa.

GlaxoSmithKline, Merck and Johnson & Johnson are struggling to recruit volunteers with enough exposure to the disease to prove whether their vaccines are doing the job and preventing infection.

The story might have been very different with just another three or four months of disease spread, underscoring the need to act more quickly to develop vaccines for emerging diseases....

Guinea, where Ebola is still infecting new victims, as "the only hope" for showing efficacy, according to Kieny and to Adrian Hill, director of the Jenner Institute at Britain's Oxford University.

The WHO is overseeing the so-called ring vaccination study in Guinea in which close contacts and family around each new case of Ebola are vaccinated -- either immediately or after a three-week delay -- to see if the shot offers protection.

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Turn on the taps to defeat the next Ebola

IRIN by Jennifer Lazuta                                 June 15, 2015

DAKAR, Senegal - It is a cruel irony that many of the top doctors and nurses in Guinea, Liberia and Sierra Leone will not be around to help rebuild their health systems in the wake of Ebola, having succumbed themselves to the virus.

Many families in Guinea still rely on streams and lakes for their water needs.Photo: Jennifer Lazuta/IRIN

 For those that are, the biggest challenges are likely to be electricity, sanitation, and, most of all, water.

“How is it possible to build, or rebuild, as you may call it, a health institution or hospital without [access to] water, which serves as a major catalyst to run the facility?” asked Moses Tamba, a spokesperson for Liberia’s Ministry of Public Works. “It is not possible. You need water....”

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Seeking the Source of Ebola

The latest Ebola crisis may yield clues about where it hides between outbreaks.

GLOBAL LITERACY PROJECT                                       June  15, 2015
abstract of article in
   
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   Picture of a masked bush meat hunter. Peter Muller.

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As Ebola Crisis Wanes, a Mixed Picture of Economic Recovery for Households in Sierra Leone

THE WORLD BANK                                                                       June 15, 2015

WASHINGTON—Employment in Sierra Leone has returned to pre-crisis levels, though earnings and hours worked still lag behind. This is according to respondents in the latest round of high-frequency mobile-phone surveys, led by Statistics Sierra Leone with support from the World Bank Group, assessing how Ebola is impacting people’s livelihoods.

The survey contacted a sample of 1,715 households during May, 2015, which represents 41 percent of the 4,199 households covered in the baseline, nationally-representative Labor Force Survey conducted in July and August 2014.

 “Sierra Leone is working tirelessly to get to zero cases of Ebola,” said Francis Ato Brown, World Bank Group Country Manager for Sierra Leone. “Our job has to be not only to support the country in eradicating Ebola, but also to look toward economic recovery and toward mitigating the short-, medium-, and long-term impacts of the crisis on the social and economic wellbeing of all Sierra Leoneans.

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Health Authorities Repeating Mistakes in Ebola Fight: MSF

      

A Sierra Leonean doctor practises wearing protective clothing in the Ebola Training Academy in Freetown, Sierra Leone, December 16, 2014.  Reuters/Baz Ratner

AFP - June 13, 2015

Dakar (AFP) - Health authorities are repeating the mistakes of the past in combatting Ebola, more than a year after its onset in Guinea and Sierra Leone, the international president of Doctors Without Borders (MSF) warned.

Joanne Liu's remarks on Saturday come a day after Sierra Leone imposed a three-week daytime curfew in the last Ebola-hit areas in a bid to curb a resurgence of the deadly virus, which has killed about 3,900 people in the country.

Neighbouring Liberia was declared Ebola-free in May, but hopes that Sierra Leone and Guinea would quickly follow suit have been dashed in recent weeks.

"We are still making the same mistakes as we did in the past," said Liu.

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Favipiravir—a prophylactic treatment for Ebola contacts?

THE LANCET byMichel Van Herp, Hilde Declerck and Tom Decroo June 13, 2015

.. the efficacy of candidate Ebola vaccines for primary prevention has not been proven.2 Furthermore, in communities in which Ebola transmission might be ongoing, an important question is: how will such a vaccination be perceived if a vaccinated person develops Ebola? Such a scenario is possible in people who contract Ebola virus before vaccination. If a person is infected with Ebola virus before vaccination, the vaccine might have a post-exposure prophylactic effect. However, how effective this prophylaxis might be is unknown.2 Moreover, if someone is infected more than 48 h before vaccination, the post-exposure prophylactic effect is likely to be insufficient, leading to possible development of Ebola after vaccination. This scenario is likely to result in serious issues relating to community trust and acceptance of an Ebola vaccine.3 How to exclude Ebola among people presenting with post-vaccination fever is also an issue.2

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Home > Health Sierra Leone Leader Imposes Curfew in Bid to Halt Ebola

 

FREETOWN -- Sierra Leone's president imposed new restrictions Friday preventing people from entering or leaving two chiefdoms in the northern part of the country that are experiencing a resurgence of Ebola.

While neighboring Liberia has defeated Ebola, Sierra Leone and Guinea have continued to battle new cases, particularly along the border where those two countries meet.

Sierra Leone had 15 news cases in the week ending June 7, according to the World Health Organization, the highest weekly total since late March.

On Friday, President Ernest Bai Koroma said people would be barred from entering or leaving the affected parts of Kambia and Port Loko districts in northern Sierra Leone. A 21-day curfew also will be in effect from 6 p.m. to 6 a.m., government officials said, though the public health benefit of such a limited measure was not immediately clear.

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How close is the Ebola vaccine?

PUBLIC BROADCASTING CORP by Caleb Hellerman         June 11, 2015

The quest for an Ebola vaccine has been a journey filled with excruciating delays and mad dashes. The latest outbreak in West Africa caused governments and drug companies to jumpstart research that had languished back when the threat of Ebola wasn’t big enough to sustain a commercial market. (Prior to 2013, the virus had sickened fewer than 2,300 people in known history). Human safety trials of two vaccines began last summer — each being given to a small group of healthy volunteers. When no major side effects were apparent, health officials scrambled to launch larger tests in the countries that were most affected by Ebola.

A volunteer receives an Ebola vaccine in Sierra Leone. Thousands of these voluntary immunizations have been tested so far in the West African nation. Photo by Cameron Hickey.

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A Chinese Ebola Drug Raises Hopes, and Rancor

NEW YORK TIMES   by Sheri Fink, MD                                                      June 12, 2015   

After a nurse who contracted Ebola in Sierra Leone was discharged Wednesday from a Rome hospital, a doctor there described the experimental treatments the patient had received as “absolutely miraculous.”

The lab at Beijing Mabworks, which developed the experimental drug, MIL77, used to treat Ebola. Credit Adam Dean for The New York Times

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International Ebola Recovery Conference Ending Ebola: “Get to Zero, Stay at Zero and Rebuild”

Congo Town, Freetown, Sierra Leone. Photo: Dylan Lowthian/UNDP

Image: Congo Town, Freetown, Sierra Leone. Photo: Dylan Lowthian/UNDP

africa.undp.org - May 9th, 2015

United Nations Secretary-General Ban Ki-moon will host an International Ebola Recovery Conference in July to ensure that the affected countries receive the resources and support they need to overcome the wider socio-economic consequences of the ongoing Ebola outbreak.

The conference at United Nations Headquarters in New York on 10 July 2015 will take place in cooperation with the Governments of Guinea, Liberia and Sierra Leone, together with other partners. 

With numbers of Ebola cases have dropped, the affected countries still need the support of the international community to get to zero cases, stay there, and to move forward on the road to recovery.

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